宁夏羊“黄染病”病因的研究  

STUDY ON THE PATHOGENSIS OF “HUANG RAN”DISEASE IN SHEEP

作　　者：蔡文华[1] 邹康南[1] 文永昌 

机构地区：[1]南京农业大学兽医学系 [2]南京农业大学土壤农业化学系

出　　处：《南京农业大学学报》1991年第1期70-76,共7页Journal of Nanjing Agricultural University

摘　　要：宁夏灵武地区的舍饲羊群中每年春季流行一种病因不明的“黄染病”,以引起肝脏与肾脏病变和皮下、内脏组织黄染为特征。发病与饲喂发霉饲草有关。从13份霉单样品中分离到12个属18个种群的真菌。有12份草样检出杂色曲霉(Aspergillus verMcolor),累计菌落敷占总菌落数的32.45％。有7份草样检出构巢曲霉(A.nidulans)。试验证明,这两种曲霉都能产生杂色曲霉素(Sterigmatocystin,ST)。13份草样的氯仿粗提物中有7份含有ST,含量为0.32～0.85mg/kg。霉饲草毒性试验可引起山羊发病死亡。从分离到的杂色曲霉和构巢曲霉的培养物提取的粗毒素也能使小白鼠和实验山羊中毒死亡。病理学观察均表现中毒性肝炎和肾炎,与病区自然发病羊的病变基本一致,从而证实羊“黄染病”是一种以杂色曲霉素为主的真茼毒素中毒病。An unknown endemic sheep disease occurred in Ningxia Hui Autonomous Region for many years.It is characterized by the degeneration of liver and kidneys, and yellow coloration on subcutaneous tissue and vicera. The occurrence was related to feeding with moldy millet straw. The identified mycoflora of 13 suspected millet straw samples were in 12 genus, 18 species. Aspergillus verstcolor was the dominant fungus(12/13), making up 32.45% of the total colonies from all species; and A. nidulans was isolated in 7/13. These two species both can produce Sterigmatocystin (ST). Of the 13 samples, crude extracts 7 had ST, the contents being 0.32～0.85mg/kg. In feeding trials the moldy millet straw and crude extracts of A. versicoior and A. nidulans both can cause goats to die. Pathological observation demonstrated it was toxic hepatitis and nephritis, the same in lesion as 'Huang Ran' disease. So the author confirmed that the sheep 'Huang Ran' disease was a mycotoxicoses mainly caused by Sterigmatocystin.

关 键 词：羊 黄染病 病因 

分 类 号：S858.265.4[农业科学—临床兽医学]