虫草菌多糖保健粉的大鼠胚胎毒性和致畸性  

THE EMBRYOTOXICITY AND TERATOGENICITY OF CORDYCEPS SINENSIS POLYGLUCOSE POWDER IN RATS.

作　　者：杨萍[1] 沈其萍[1] 何丽芳[1] 

机构地区：[1]云南省卫生防疫站,昆明650022

出　　处：《现代预防医学》2001年第3期275-276,共2页Modern Preventive Medicine

摘　　要：目的 :了解虫草菌多糖保健粉的大鼠胚胎毒性和对胎儿的致畸性。方法 :应用传统致畸试验。结果 :各剂量组胎鼠毒性和畸形与阴性对照组比较无显著性差异 ,而给予极高剂量 (达 5 0 0 0 mg/ kg. bw )时 ,孕鼠体重增重显著性低于阴性对照组。结论 :虫草菌多糖保健粉对孕鼠体重增重有一定的影响 。Objective:The embryoxicity and teratogenicity studies of Cordyceps sinensis(Berk.) Sacc amylose powder were conducted in rats by traditional teratogenicity test.Result:The frequency of terates and the embryotoxicity of the fetus in each dose group were not significantly different as compared with negative control group.However,in very high dose(up to 5000mg/kg.bw),the growth of body weight in gestation of rats were significant lower than negative control.Conclusion:The Cordyceps sinensis(Berk.) Sacc amylose powder had slight effect on the body weight growth of pregnant rats,and possesses no embryotoxicity and teratogenicity.

关 键 词：虫草菌多糖保健粉 胚胎毒性 致畸性 中药 

分 类 号：R285.1[医药卫生—中药学]