医院致病菌对24种抗菌药物药敏结果与评价  

THE RESULTS AND EVALUATION OF THE ANTIBIOTIC RESISTANCE TEST OF PATHOGENS IN HOSPITAL TO 24 KINDS OF ANTIBIOTICS.

作　　者：王芳[1] 匡维华 黄小霞[3] 龙晚生[4] 

机构地区：[1]广东江门市中心医院药剂科,广东江门529070 [2]广东江门出入境检验检疫局,江门529000 [3]广东江门市中心医院药剂科检验科 [4]广东江门市中心医院药放射科

出　　处：《现代预防医学》2001年第3期397-400,共4页Modern Preventive Medicine

摘　　要：目的 :研究致病菌对临床常用抗菌药物的耐药性 ,及两年中耐药性的变迁 ,为医院感染控制提供参考。方法 :回顾性分析 2年间临床分离的细胞 1432株 ,按双歧索引法鉴定菌种。抗生素敏感性测定采用 KB纸片法。按美国质量标准委员会 (NCCL S) 1999年、 2 0 0 0年标准判断结果。结果 :(1)致病菌株中革兰阴性杆菌 (G- )以大肠埃希菌和铜绿单孢菌为主 ,分别占 35 %和 16 .9% ;革兰阳性球菌 (G+ )以凝固酶阴性葡萄球菌 ,粪肠球菌和金葡球菌为多见 ,分别占 5 8%、 16 .2 %和 14%。 (2 )药敏试验显示 G-细菌对氨苄西林、阿莫西林 /克拉维酸钾的耐药率分别为 83.1%和 80 .1% ;对亚胺培南 /西司他丁钠、头孢哌酮 /舒巴坦、头孢他啶、阿米卡星的耐药率分别为 10 .5 %、 11.3%、 2 5 .9%和 2 6 .1%。G+细菌对青霉素钠的耐药率高达 88.9% ;万古霉素对 G+细菌具有显著的抗菌活性 ,其次为亚胺培南。结论 :高耐药性致病菌检出率 2年中显著上升 ,且致病菌的耐药性也明显增长。Objective:To study the pathogens drug resistance to antimicrobial agents and the variation of drug resistance during 2 years.Methods:Clinical cases were studied by retrospective investigation.We identified the bacteria of 1432 strains from isolation culture of clinical samples by Bifido Index Method.The sensibility of the bacteria to antibiotics were examined by KB paper method.The result based on the National Committee for Clinical Laboratory Standards(NCCLS).Results:(1)Most of the G - bacteria were colibacillus(35%) and pseudomonas aeraginosa(16 9%).Most of the G + bacteria were coagulase netative staphylococcus(58%)?enterococcus faecalis(16 7%) and staphylococcus aureus(14%).(2)The resistance rate of the G - bacteria to amipicillin,amoxicillin/clovulanic acid was 83 1% and 80 1%;to imipenem?cefoperazone/sulbactam?ceftazidime?amikacin was 10 5%?11 3%?25 9% and 26 1%,respectively.More than 85%(88 9%) of the G + bacteria were resistant to penicillin.Vancomycin showed fairly high activity against the G + bacteria among the antimicrobial agents tested,so did imipenem.Conclusion:There were significant increase in drug resistance rate of pathogens between 1999 and 2000.The high drug resistant pathogens appearant rate of our hospital raised apparently in the past 2 years.It is very important to use antibiotics properly for infection diseases control and hospital infection management.

关 键 词：致病菌 耐药性 抗菌素 革兰阴性杆菌 

分 类 号：R378[医药卫生—病原生物学]