Hassab手术后肝硬变大鼠动脉血酮体比改变的意义  

The Significance of Arterial Blood Ketone Body Ratio Changes in Rats with Hepatic Cirrhosis after Hassab Operation

作　　者：王水[1] 张保康[1] 赵同生 

机构地区：[1]南京医学院第一附属医院普外科

出　　处：《南京医学院学报》1991年第4期302-305,共4页

摘　　要：采用改良的水杨醛比色法测定健康和肝硬变大鼠门奇静脉断流术(Hassab手术)前、后不同时相动脉血乙酰乙酸/β-羟丁酸比(简称血酮体比);同时测定肝组织能荷值。结果发现硬变肝术后有发生功能衰竭的倾向。实验还表明,手术前、后血酮体比与肝能荷改变呈正相关(健康鼠组:r=0.906,P<0.001; 硬变肝鼠组:r=0.807,P<0.001),认为该比值是评价术后肝功储力较好的方法之一。The clinical status of porto-azygotic devas cularization (Hassab's operation) inrats with hepatic cirrhosis and normal rats was compared.The results showed that the enegymetabolism in animals with liver cirrhosis was impaired to some extent prior to surgeryand their energy charge levels were demonstrated to decline significantly 8 hours aftersurgery which was contrary to that found in rats with normal liver. It is supposed that theabove changes in association with cirrhosis are likely to be responsible for the developmentof hepatic failure. For estimating the ratio of acetoacetate to β-hydroxybutyrate(ketone bodyratio, KBR), a modified salicyladehyde colorimetric method was adopted. Changes in KBRof arterial blood were found to be positively correlated with that of hepatic energy Chargebefore and after operation(normal: r=0.906,P<0.001; cirrhotic: r=0. 807, P<0. 001). ThusKBR as a parameter reflecting hepatocyte metabolic function could be applied to determinepostoperative dynamic changes of liver function.

关 键 词：肝硬变 HASSAB手术 动脉血酮体比 

分 类 号：R657.31[医药卫生—外科学]