一种新的标记配合物^(99m)TcN-tetrofosmin的制备及其动物分布的初步研究  

The preparation and preliminary animal experiment of a new complex: ^(99m)TcN-tetrofosmin

作　　者：陆洁[1] 吕恭序[1] 王学斌[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《核技术》2001年第11期925-928,共4页Nuclear Techniques

摘　　要：在成功制备 [99mTcN]2 + int 核中间体的基础上 ,通过配体交换反应制得放化纯度大于 95 %的99mTcN -tetrofosmin标记配合物。该配合物在制备后室温放置 6h、放化纯度基本不变 ;小鼠生物分布实验表明其在心肌有一定的摄取和较好的滞留 ,血、肺清除较快 ,有较高的心 /血和心 /肺比 ,心 /肝比值在注射后 2h可大于 1。On the basis of successfully obtained [ 99m TcN] 2+ int core, the complex 99m TcN-tetrofosmin was prepared through the ligand-exchange reaction. The radiochemical purity of 99m TcN-tetrofosmin was over 95% by TLC. A study of stability indicated the complex was stable over 6h at room temperature. The mice biodistribution of 99m TcN-tetrofosmin showed the accumulation in myocardium with high retention and rapid blood and lung clearance.

关 键 词：心肌显像剂 TETROFOSMIN ^99mTcN-tetrofosmin 心肌疾病 生物分布 锝99 标记配合物 放射性核素 诊断 

分 类 号：R817.42[医药卫生—影像医学与核医学]