C_(60)衍生物的放射性碘标记  

Radioiodination of C_(60) derivative

作　　者：李宇国[1] 张晓东[1] 李晴暖[1] 李文新[1] 

机构地区：[1]中国科学院上海原子核研究所,上海201800

出　　处：《核技术》2001年第11期959-960,共2页Nuclear Techniques

基　　金：国家自然科学基金项目 (19975 0 6 6 )

摘　　要：In this paper water-soluble C 60 derivative was iodolabelled radioactively with Iodogen method. The labelled yield was measured by Silica GF254 TLC. The effects of pH value, time, temperature and the amount of Iodogen on the labelled yield were studied. 125 I-C 60 (OH) x O y was purified by Sephadex G-25 column chromatography and then the stability of 125 I-C 60 (OH) x O y was examined. The results showed that the radiochemical purity of 125 I-C 60 (OH) xO y solution with 2% benzylalcohol remained 82.7% after 43h.In this paper water-soluble C 60 derivative was iodolabelled radioactively with Iodogen method. The labelled yield was measured by Silica GF254 TLC. The effects of pH value, time, temperature and the amount of Iodogen on the labelled yield were studied. 125 I-C 60 (OH) x O y was purified by Sephadex G-25 column chromatography and then the stability of 125 I-C 60 (OH) x O y was examined. The results showed that the radiochemical purity of 125 I-C 60 (OH) xO y solution with 2% benzylalcohol remained 82.7% after 43h.

关 键 词：富勒烯 C60(OH)xOy 标记 稳定性 碳60 衍生物 碘125 放射性核素 放射性药物 

分 类 号：R817.9[医药卫生—影像医学与核医学]