高比活度〔甲基-~3H〕-胸腺嘧啶核苷的制备  

The Preparation of High Specific Activity Methyl-~3H-TdR

作　　者：王晓静[1] 郑宗琪[1] 郭振[1] 朱青[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413

出　　处：《同位素》2001年第3期205-209,共5页Journal of Isotopes

摘　　要：以 (5 - F3 ) -胸腺嘧啶核苷 (Td R)为前体 ,采用 Pd O/ Ba SO4 为催化剂 ,在 2 .5 mo L/ L KOH水溶液中进行催化卤氚取代反应。获得的标记物比活度为 9.1TBq/ g,与目前所用方法制备的标记物比活度 3TBq/ g相比提高 2倍。标记物放化纯度 >95 % ,示踪灵敏度可提高 70The methyl 3H TdR is prepared by a catalytic reaction of substituting tritium based on (5 F 3) TdR as precursor and PdO/BaSO 4 as catalyst. The optimum conditions of tritating, separating and purifying, as well as the store of the labeled compound are selected. The specific activity of the tritation is 9.1 TBq/g which is two times higher than those prepared by other method. The radiochemical purity of the tritation is more than 95%, and the tracer sensitivity can be improved more than 70%.

关 键 词：[甲基-^3H]-TdR 高比活度 制备 [甲基-^3H]-胸腺嘧啶核苷 放射性比活度 氚 标记 胸腺嘧啶核苷 

分 类 号：Q525[生物学—生物化学] TL923[核科学技术—核燃料循环与材料]