新生儿HIE血清IL-6、IL-8与TNF-α动态变化及临床意义探讨  

PERIPHERAL BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-8 AND TUMOR NECROSIS FACTOR-ALPHA IN NEONATAL HIE AND ITS CLINICAL SIGNIFICANCE.

作　　者：刘敬 吴广琴[2] 郭秀霞[3] 张霞[3] 李雪梅[2] 

机构地区：[1]北京燕化医院儿科,102500 [2]北京天坛医院 [3]河北省石家庄市妇产医院

出　　处：《新生儿科杂志》2001年第4期145-146,161,共3页The Journal of Neonatology

摘　　要：为探讨新生儿缺氧缺血性脑病 (HIE)外周血IL -6、IL -8与TNF -α变化的临床意义 ,采用放射免疫法 ,对生后 1天 ( 2 4小时内 )、3天及 7天检测了 40例HIE患儿及 40例正常新生儿外因血IL 6、IL 8与TNF α水平。结果显示 ,与正常新生儿比较 ,HIE患儿生后 1天血清IL -6水平分别为 ( 5 2 6± 2 4 5 )对 ( 80 2± 2 9 4)ng L(P <0 0 1) ,IL -8分别为 ( 0 47± 0 13)对 ( 0 6 8± 0 16 ) μg L(P <0 0 1) ,TNF -α分别为( 1 18± 0 31)对 ( 0 91± 0 30 ) μg L(P <0 0 1) ,而且病情越重改变越明显 ;至生后 1周IL -6、TNF -α恢复至正常 ,与对照组水平相比P >0 0 5 ,而IL -8则仍显著低于正常新生儿 (P <0 0 1)。因此 ,认为围产期窒息与HIE患儿外周血IL -6与IL -8水平减低 ,TNF -α水平升高 ;它们可能参与了新生儿缺氧缺血性脑损伤的某些发病过程。In oder to assess the influence of birth asphyxia and HIE on interleukin 6,interleukin 8 and tumor necrosis factor alpha of peripheral blood levels in asphyxiated neonates and to analyze the clinical significance, by using immunoassays and peripheral blood at time of 1 day? 3 day and 7 day after birth from 80 full term neonates classified into two groups acording to the presence or absence of birth asphyxia and HIE. Results showed birth asphyxia was associated with a decrease in IL 6 (52 6±24 5) vs (80 2±29 4) ng/L ( P <0 01) and in IL 8 (0 47±0 13) vs (0 68±0 16) μg/L ( P <0 01) and an increase in TNF α(1 18±0 31) vs (0 91±0 30) μg/L( P <0 01). It may be concluded that birth asphyxia and HIE were associated with elevated TNF α cord blood levels in full term neonates while with asphyxia was associated with decreased IL 6 levels and IL 8.

关 键 词：新生 HIE 外周血 IL-6 IL-8 TNF-Α 缺氧缺血性脑病 

分 类 号：R722.121[医药卫生—儿科]