急性缺血缺氧对胎鼠血清IGFs水平和宫内发育的影响  

EFFECT OF ACUTE ISCHEMIC-HYPOXEMIA ON SERUM IGSF LEVELS AND INTRAUTERINE GROWTH OF RAT FETUS

作　　者：白波 陈波[2] 李炜如[3] 姚裕家[3] 曾懿[3] 杨帆[3] 

机构地区：[1]广东省花都市人民医院,510800 [2]四川省攀枝花钢铁公司职工医院儿科 [3]华西医科大学附二院儿科

出　　处：《新生儿科杂志》2001年第4期159-161,193-194,共3页The Journal of Neonatology

摘　　要：为探讨急性缺血缺氧对胎儿血清IGF Ⅰ、 Ⅱ水平的影响和IGFs在胎儿发育中的作用 ,对 2 1只SD孕鼠被随机分为对照组 9只 ,实验组 1 2只。钳夹实验组孕鼠双侧子宫动、静脉 2 0分钟建立胎鼠缺血缺氧模型 ,对照组仅行开腹和关腹术。比较两组胎鼠血清IGFs、血糖水平及生长参数和器官重量。结果显示 ,实验组血清IGF Ⅰ、 Ⅱ及血糖浓度分别为 1 1 7 92± 2 6 58ng ml,2 33 1 9± 33 35ng ml及 41 6 7±5 6 1mg dl,明显低于对照组 (分别为 2 34 43± 70 6 5ng ml,397 74± 2 3 6 9ng ml及 6 6 4± 4 95mg dl,P均 <0 0 0 1 ) ,其生长参数和器官重量亦明显低于对照组 (P均 <0 0 0 1 )。因此 ,宫内短期的急性缺血缺氧即可致胎儿宫内发育迟缓 (IUGR) ;In oder to investigate the effect of acute ischemic hypoxemia on fetal serum levels of IGF Ⅰ, Ⅱ and the actions of IGFs during fetal growth, 21 pregnat SD rats were randomly divided into experimental group (n=12) and control group (n=9). The bilateral uterine arteries and veins of dams in experimental group were clamped for 20 minuates in order to build rat fetus model of ischemic hypoxemia and a sham surgery was performed in control group. The fetal serum concentrations of IGFs, blood glucose and growth garameters, organic weights of fetal rats in both groups were measured and compared. Results showed the serum IGF Ⅰ, Ⅱ and blood glucose coucentrations (117 92±26 58ng/ml,233 19±33 35ng/ml and 41 67±5 61 mg/dl, respectively) in experimental group were significantly lowe ( P <0 001) than those in control group (234 43±70 65ng/ml,397 74±23 69ng/ml and 66 4±4 95mg/dl,respectively), as well as the growth parameters, organic weights were significantly lowere ( P <0 001) than those in control group. Therefore temporal acute intrauterine ischemic hypoxemia may result in intrauterine growth retardation (IUGR) and the decrease of IGFs levels may be the important factors contributing to fetal IUGR.

关 键 词：缺血缺氧 胰岛素样生长因子 宫内发育迟缓 胎鼠 IUGR 

分 类 号：R722.121[医药卫生—儿科]