血浆置换治疗巨球蛋白血症  

Treatment of macroglobulinemia with plasmapheresis

作　　者：杨忠心[1] 何惠君[1] 魏晴[1] 王洪源[1] 涂同涛[1] 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院输血科,430030

出　　处：《临床内科杂志》2001年第6期431-433,共3页Journal of Clinical Internal Medicine

摘　　要：目的　探讨血浆置换 ( plasma exchange,PE)对原发性巨球蛋白血症的治疗效果。方法　使用 Haemonetic- V5 0型血细胞分离机对 6例巨球蛋白血症患者进行血浆置换 ,平均 14 0 0ml/次 ,每人平均置换 6.6次 ,并辅以化疗 ,观察治疗前后主要实验室指标的变化。结果　经 PE治疗后血浆粘度和异常单克隆 Ig M球蛋白明显降低。结论　血浆置换能明显降低血粘度 ,是治疗巨球蛋白血症的有效方法。Objective To determine the therapeutic effectiveness of plasmapheresis on primary macroglobulinemia. Methods Haemonetic V50 blood cell separation machine was used to carry out plasmapheresis in 6 patients,the amount of plasmapheresis was approximately 1400ml per person each time, along with chemotherapy. The main laboratory indices were observed before and after treatment. Results After plasmapheresis, plasma viscosity and abnormal monoclone IgM decreased markedly. Conclusion Plasmapheresis can markedly decrease plasma viscosity and is an effective treatment for macroglobulinemia.

关 键 词：血浆置换 巨球蛋白血症 治疗 血粘度 

分 类 号：R553[医药卫生—血液循环系统疾病] R457.1[医药卫生—内科学]