长期应用培哚普利与氨氯地平对高血压病患者左心室舒张功能的影响  

Influence of long-term perindopril or amlodipine on left ventricular diastolic function in hypertension

作　　者：徐华清[1] 邬松林[1] 秦海燕 

机构地区：[1]武汉大学人民医院 [2]湖北省黄冈市人民医院

出　　处：《临床内科杂志》2001年第6期442-444,共3页Journal of Clinical Internal Medicine

摘　　要：目的　比较长期服用钙拮抗剂与血管紧张素转化酶抑制剂对高血压患者左心室舒张功能的影响。方法　将 78例轻、中度高血压患者随机分成两组 ,一组服用培哚普利 ,另一组服用氨氯地平 ,疗程一年 ,目标血压 <14 0 / 90 mm Hg。采用超声心动图评估患者治疗前、治疗后 3、6、12个月的左心室舒张功能。结果　 68例患者完成实验 ,其左心室舒张功能指标如 E峰、A/ E比率、E峰下降速率较治疗前显著升高 ,而 A峰相关指标则较治疗前显著降低。Objective To compare the influence of calcium channel antagonists and angiotensin converting enzyme inhibitors (ACEI) on left ventricular diastolic function of essential hypertension (EEH).Methods 78 patients with mild and moderate hypertension were randomly divided into two groups. One was treated with perindopril, the other with amlodipine for one year, to reduce their blood pressure to the target blood pressure (<140/90 mmHg). Their left ventricular diastolic function (LVDF) were evaluated by echocardiography before treatment and 3 months, 6 months, 12 months after treatment.Results 68 patients finished experiment. All 68 patients who took the above drugs for one year got the target blood pressure. Their LVDF such as E peak velocity, A/E ratio, E peak decrease velocity were significantly increased than that of pre treatment, while indexes relative A peak remarked decreased.Conclusion LVDF of EEH can be improved greatly by long term taking perindopril or amlodipine.

关 键 词：哚普利 氨氯地平 高血压 药物疗法 治疗 左心室舒张功能 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]