羟磷灰石聚乙烯复合生物活性涂层的生物力学评价  

BIOMECHANICAL EVALUATION OF HYDROXYAPATITE -POLYETHYLENE COMPOSITE COATING

作　　者：施忠民[1] 

机构地区：[1]上海市第六人民医院骨科,200233

出　　处：《医用生物力学》2001年第3期179-182,共4页Journal of Medical Biomechanics

摘　　要：目的：对具有生物活性的羟磷灰石聚乙烯复合涂层进行生物力学性能评估。方法：利用狗经皮质骨植入模型，以无涂层钛合金假体作为对照，植入一定时间后，在力学实验机上，分别对羟磷灰石聚乙烯复合涂层和对照组进行推出实验，测定骨－涂层界面剪切强度。结果：羟磷灰石聚乙烯复合涂层各时间组的剪切强度值均大于无涂层对照组，是对照组的３∽５倍，统计学有显著差异(方差分析Ｐ＜０．０１)。剪切强度随时间增加而增强，至１２周达最大值。结论：羟磷灰石聚乙烯复合涂层其界面剪切强度比无涂层对照组明显增大，显示其良好的生物力学性能，为达到长期生物学固定提供了一种有效方法。To evaluate the biomechanical differences of Hydroxyapatite-Polyethylene composite coating and uncoated Ti-alloy implants. Methods The canine transcortical implant model was utilized At the end of the implantation periods push-out tests were carried out to acquire bone-coating interface shear strength of hydroxyapatite-polyethylene coating with uncoated Ti-alloy implants as control. Results The hydroxyapatite-polyethylene coating in every group showed greater shear strengths than uncoated implants being 3-5 times as much. The difference was significant statistically. (P<0.01) The strength increased with time reached the peak value at 12 weeks. Conclusions The interface shear strength of hydroxyapatite-polyethylene composite coating was much greater than that of the uncoated implants the results have revealed its good biomechanical characteristics which provided an effective method of biological fixation.

关 键 词：羟磷灰石 聚乙烯 复合涂层 种植体 生物力学 人工关节假体 

分 类 号：R318.17[医药卫生—生物医学工程] R318.01[医药卫生—基础医学]