珍珠七十丸对大鼠的长期毒性及其血铅、肾汞、肝砷的测定  

CHRONIC TOXIC EFFECTS OF ZHENZHU QISHI PILLS IN RATS AND THE DETERMINATION OF Pb、Hg、As

作　　者：陈淑杰[1] 刘卫建 颜芳[3] 周群英[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]西藏自治区藏医院药物研究所,西藏850000 [3]成都中医药大学,四川成都610075

出　　处：《华西药学杂志》2001年第5期348-349,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :考查长期给予大鼠珍珠七十丸的毒性及测定其体内铅、汞、砷的含量。方法 :口服给药 3月后 ,检测血象 ,肝、肾功能和铅、汞、砷的含量。结果 :用药 3月后 ,RBC减少 ,WBC、Hb、HCT等无差异 ;对肝、肾功能有一定的影响 ;铅、汞、砷含量虽比对照组均有升高 ,但低于人的含量。结论 :大鼠口服珍珠七十丸的用量高于人临床试用量的 30倍和 90倍 ,连续给药 3月后对少部分指标有一定影响 。OBJECTIVE:To study the chronic toxicityofratsorally administrated(ig) Zhenzhu Qishi pills for a long period, and determine the contents of Pb?Hg?As in the body.METHODS:After orally taking the drug for 3 months,a rat is examined on its hemogram?functions of liver and kidney,the contents of Pb?Hg?As.RESULTS:After ig 3 months,RBC of rats reduced while WBC?Hb?HCT had few changes.It had some effects on the functions of liver and kidney.The contents of Pb?Hg?As increased to be compared with control,but it is still under the level of man's.CONCLUSION:A rat is given Zhenzhu Qishi pills with dosage of 30 and 90 times of a man's. After about 3 months,it has no change.So the drug is safe.

关 键 词：珍珠七十丸 长期毒性 铅 汞 砷 测定 

分 类 号：R285.5[医药卫生—中药学]