先天性心脏病与宫内肠道病毒感染  

Intrauterine enterovirus in fection of patients with congenital heart diseaes

作　　者：王雪梅[1] 韩玲[2] 刘晓晔[2] 

机构地区：[1]北京大学第三医院儿科,北京100083 [2]北京市安贞医院儿科

出　　处：《中国优生优育（1990-2002上半年）》2001年第3期131-132,共2页Journal of Improving Birth Outcome and Child Development of China

摘　　要：目的 探讨先天性心脏病与宫内肠道病毒感染的关系。方法 用聚合酶链反应技术及核酸杂交方法检测先天性心脏病患儿心肌组织及血清中肠道病毒RNA,同时检测患儿血清中柯萨奇B病毒特异IgM、IgG抗体,取非心脏病原因死亡的新生儿心肌标本及非心脏病人的血清作为对照。结果 先天性心脏病患儿心肌标本中肠道病毒RNA检测阳性率明显高于非心脏病组,而血清柯萨奇B特异IgM、IgG抗体检测阳性率与非心脏病组差异无显著性。结论 先天性心脏病可能与宫内肠道病毒感染有关,且生后病毒仍持续存在于心肌组织中。Objective To study the relationship between congenital heart disease (CHD)and intrauterine infection of enterovirus (EV). Methods Polymerase chain reaction and nucleic hybridization were used to detect EV RNA in myocardial tissues and sera of CHD patients. Enzym - immunosobent assay was used to detect coxsackie virus specific IgM, IgG antibody in sera of CHD patients. Myocardia tissues and sera of patients without CHD were also detected as controls. Results The positive rate of EV RNA in myocardia tissue of CHD patients was significantly higher than that of control group; There was no marked difference for the positive rate of CVB specific IgM, IgG between the two groups. Conclusion CHD may be caused by intrauterine inrfction of EV and EV may exsist in myocardial tissue after birth.

关 键 词：先天性心脏病 聚合酶链反应 心肌组织 新生儿 宫内肠道病毒感染 

分 类 号：R725.4[医药卫生—儿科]