西藏高原先心病患者围心脏手术期血液流变学分析  

Analysis of Hemorheology for Congenital Heart Disease Perioperative on Tibet Platera

作　　者：李景文[1] 王资斌[2] 拉巴次仁[2] 龙村[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院体外循环科,100037 [2]西藏自治区人民医院胸心外科

出　　处：《中国血液流变学杂志》2001年第3期210-212,共3页Chinese Journal of Hemorheology

摘　　要：目的　探讨西藏高原先心病患者心脏手术期间的血液流变学变化。方法　观察高原组 (12例 )和平原组(12例 )患者术前、转流 30分、停机后、术后 1天、术后 3天、术后 5天及术后 7天的不同切变率下的全血粘度、血浆粘度、全血还原粘度、红细胞压积、红细胞刚性指数及红细胞聚集指数。结果　转流期间的各切变率下的全血粘度、血浆粘度均降低 (P <0 .0 5 ) ,术后 1天恢复 ;红细胞压积、红细胞聚集指数也降低 (P <0 .0 5 ) ,术后 7天才恢复 ;红细胞刚性指数升高 (P <0 .0 5 ) ,术后 7天恢复。除红细胞刚性指数高原组小于平原组 (P <0 .0 5 ) ,其他指标高原组均大于平原组 (P <0 .0 1)。结论　高原先心病患者围心脏手术期全血粘度、红细胞聚集性高 ,红细胞变形性较好 ,采用控制性稀释技术 。Objiective:To study the change of hemorheology for cogenital heart disease during cardiopulmonary bypass on Tibet Plateru.Method Date from 12 patients of plain group and 12 patients of plateau group were compared including whole blood viscosity,plasma viscosity,whole blood viscosity hematocrit,erythrocyte rigid index,erythrocyte aggregation index of various shear rate during CPB 30 minutes,out of CPB,one day,three day,five day,seven day after surgery,respectively.Results Plasma viscosity and whole blood viscosity reduced during CPB and restored one day after surgery;hematocrit and erythrocyte aggregation index also reduced,and restored seven day after sugery;eryghrocyte rigid index was lower on plateau than on plain,but the other was higher on plateau than on plain.Conclusion Whole blood viscosity,erythrocyte aggregation index,erythrocyte transformation were better on plateau than on plain.Controlled dilute technique is benefit to microcirculation perfusion.

关 键 词：体外循环 血液流变学 高原 平原 先天性心脏病 围手术期 

分 类 号：R654.1[医药卫生—外科学] R331.1[医药卫生—临床医学]