甲型肝炎减毒活疫苗不同免疫程序的长期免疫原性比较  

Comparison of Immune Persistence of Live Attenuated Hepatitis A Vaccine with Different Immunization Schedules

作　　者：龚健[1] 李荣成[1] 罗东 黄全诚 农艺 江世平 杨进业[1] 黄月葵[1] 李艳萍[1] 徐志一[4] 汪萱怡[4] 莫建军[1] 王鹏高 刘景晔[5] 

机构地区：[1]广西壮族自治区卫生防疫站,南宁530021 [2]柳城县卫生防疫站,广西壮族自治区柳城545200 [3]柳州市卫生防疫站,广西壮族自治区柳州545001 [4]复旦大学公共卫生学院,上海200032 [5]长春生物制品研究所,吉林长春130062

出　　处：《中国计划免疫》2001年第5期249-252,共4页Chinese Journal of Vaccines and Immunization

基　　金：国家"九五"科技攻关项目 (96-90 6-0 3 -0 1)

摘　　要：为了探讨国产规范化甲型肝炎 (甲肝 )减毒活疫苗 (LA - 1株 )不同免疫程序的长期免疫原性 ,在广西壮族自治区柳城县筛检出甲肝抗体IgG阴性的 6～ 9岁儿童 15 6名 ,分为 3组 ,各组年龄和性别构成均衡。甲肝疫苗由长春生物制品研究所提供 ,滴度为 10 6 75TCID50 。A组接种 1剂甲肝疫苗 ,B组按 0、6个月程序 ,C组按 0、12个月程序分别接种 2剂甲肝疫苗。A组于免疫后 6、12、2 4、36个月 ,B、C组于第 2针免疫后 1个月、首针免疫后 12、2 4、36个月定人随访采血 ,用美国Abbott公司ImxmEIA试剂检测甲肝抗体IgG。结果显示 :A组免疫后 6～ 2 4个月的抗体阳性率88 6 %～ 91 4% ,GMT 10 5mIU/ml～ 10 6mIU/ml,第 36个月时阳性率 80 0 % ,GMT 99 2 0mIU/ml。B、C组的抗体水平变化趋势大致相同。抗体GMT均在第 2针免疫后 1个月达到高峰 ,分别为 12 0 4 6 3mIU/ml和 34 6 3 2 1mIU/ml,从峰值到第 2 4个月间 ,两组GMT分别迅速下降了 5 9%和 83% (为 489 12mIU/ml和 5 96 5 7mIU/ml) ;第 36个月 ,分别缓慢降至 45 9 6 8mIU/ml和 5 0 6 2 3mIU/ml,较第 2 4个月分别下降 6 %和 15 %。B、C组在 2针免疫后 ,抗体水平始终显著高于A组 ,在第 36个月 ,GMT分别是A组的 4 6倍和 5 1倍 ,阳性率 (97% )亦高于同期A组 (80 % )。For exploring the immune persistence of different immunization schedules of the live attenuated hepatitis A vaccine(LA-1 strain),156 children of 6～9 years old with hepatitis A IgG antibody negative selected from Liucheng County of Guangxi Zhuangzu Autonomous Region were divided into 3 groups equal in ages and sexes Group A was given one dose of hepatitis A vaccine,Group B and C were immunized according to 0,6 and 0,12 schedules respectively During follow-up of every individual,the blood specimens were collected at 6,12,24,36 months after immunization of Group A and 12,24,36 months after first dose and 1 month after second dose of Group B and C The results showed that in 3*!463 21mIU/ml respectively But during Group A,the antibody positive rate after 6～24 months was 88 6%～91 4%,the GMT was 105mIU/ml～106mIU/ml,but each of that changed to 80 0% and 99 20 mIU/ml after 36 months The tendency of antibody change in Grup B and C was about the same GMT reached to the top in Group B and C 1 month after second dose, 1*!024 63mIU/ml and the time from top GMT to 24 th month,the GMT of Group B and C decreased rapidly about 59% and 83%(489 12mIU/ml and 596 57mIU/ml) respectively,and it continually declined slowly at 36 th month to 459 68mIU/ml and 506 23mIU/ml,that were 6% and 15% lower than that at 24 th month It showed be pointed out that the antibody level in Group B and C after 2 doses were significantly higher than that in Group A from beginning to end, at 36 th month the GMT of Group B and C were 4 6 times and 5 1 times to that of Group A,the antibody positive rate(97%) was higher than that of Group A(80%) in same time So,we conclude that the live attenuated hepatitis A vaccine,the LA-1 strain,ca

关 键 词：甲型肝炎 减毒活疫苗 免疫程序 免疫原理 

分 类 号：R512.61[医药卫生—内科学]