东方田鼠感染血吸虫前后血清补体C_3 C_4水平的动态  

Dynamics on the Levels of Complement C_3 and C_4 in Sera from Microtus Fortis Before and After Infection with Schistosoma Japonicum

作　　者：张新跃[1] 何永康[1] 李毅[1] 喻鑫玲[1] 罗新松[1] 杨瑞青[1] 刘宗传[1] 

机构地区：[1]湖南省寄生虫病防治研究所,中国湖南岳阳414000

出　　处：《实用预防医学》2001年第4期244-245,共2页Practical Preventive Medicine

基　　金：卫生部血吸虫病重点项目 (总理基金 ) (94- y - 0 2 );国家科技部"九.五"攻关 (1 996 -A2 3 - 0 6 - 0 4 )资助

摘　　要：目的　检测东方田鼠感染血吸虫前后血清补体C3 、C4 水平 ,阐明其动态规律 ,为东方田鼠抗血吸虫感染的免疫机理提供证据。　方法　免疫比浊法检测血清补体C3 、C4 水平。　结果　未感染血吸虫的东方田鼠血清补体C3 、C4 平均含量显著高于昆明系小鼠 ,东方田鼠感染后血清中C3 、C4 平均水平在第 11d以前较低 ,第 2 1d升高 ,第 2 6d较前显著升高 ,昆明系小鼠感染后C3 、C4 平均水平逐渐上升 ,直至第 2 6d非常显著地高于第 2 1d之前者。　结论　东方田鼠血清补体水平较高 。Objective To detect the levels of complement C 3 and C 4 in sera from laboratory bred Microtus fortis before and after infection with Schistosoma japonicum in order to provide evidence for the immunological mechanism in M. fortis against S. japonicum infections. Methods Immuno-turbidometry was performed to detect the levels of C 3 and C 4 in sera. Result The mean levels of C 3 and C 4 in sera from normal M. fortis were significantly higher than those of mice. During the first 11 days after infection, the mean levels of C 3 and C 4 of M. fortis were comparably low, but increased significantly at day 21 and 26, whereas those of mice showed a trend of consecutive increase. Conclusion The levels of Complement C 3 and C 4 in sera from M. fortis were comparably high, which could play an improtant role in its resistance to the infection by S. japonicum.

关 键 词：东方田鼠 血吸虫 补体C3、C4 血吸虫病 

分 类 号：R532.21[医药卫生—内科学]