肿瘤坏死因子α在系膜增生性肾小球肾炎中的表达及其在发病中的作用  

The Expression and Function of TNF-αin Mesangial Proliferative Glomerulonephritis

作　　者：刘雨清[1] 张伟栋[1] 吴洪娟[1] 郭爱华[1] 吕世军[1] 刘海涛[1] 

机构地区：[1]潍坊医学院病理学教研室,山东潍坊261042

出　　处：《潍坊医学院学报》2001年第4期308-309,W006,共3页Acta Academiae Medicinae Weifang

基　　金：山东省卫生厅资助课题 (课题号 :1 997 0 1 2号 )

摘　　要：目的　探讨肿瘤坏死因子 (TNF α)在人系膜增生性肾小球肾炎中的表达及其在发病中的作用。方法　采用HE ,PAS ,PASM及免疫组织化学方法对 13例系膜增生性肾小球肾炎进行染色观察。结果　TNF α阳性反应见于肾近曲小管上皮细胞和肾小球内 ,且阳性反应强度与HE ,PAS等显示的病变程度一致。结论　TNFObjective To study the role of tumor necrosis factor (TNF α) in the development of human mesangial proliferative glomerulonephritis.Method Histotopathological (HE,PAS,PASM) analysis and immuno histochemistry were used to evaluate the change and the expression of TNF α in the tissues of kidney.Result The results showed that TNF α positive reaction were found in glumeruli and renal tubles and also reveal a relationship between the increased expression and severity of the lesions.Conclusion Increased expression of TNF α may play a important role in the pathological accumulation of extracellular matrix and renal interstitial fivrosis in mesangial proliferative glomeralonephritis.

关 键 词：系膜增生性肾小球炎 肿瘤坏死因子 免疫组织化学 

分 类 号：R692.310.2[医药卫生—泌尿科学]