对氨基水杨酸钠与EDTA治疗慢性锰中毒疗效对比  

Compared Observation of the Therapeutic Effect of PAS-Na and EDTA on Chronic Manganisnm

作　　者：高晓玲[1] 蒋志宏[1] 刘卓宝 陈健[1] 杨文草[1] 王培安[1] 

机构地区：[1]上海市第一人民医院分院职业病科,上海200081 [2]上海市疾病控制中心,200336

出　　处：《劳动医学》2001年第3期154-156,共3页

摘　　要：[目的 ]探讨对氨基水杨酸钠 (PAS Na)治疗慢性锰中毒的疗效。 [方法 ]根据GB 32 32 82诊断标准为锰中毒观察对象及慢性轻、重度锰中毒 5 2人的临床资料进行了回顾性分析 ,分为EDTA组、PAS组进行疗效对照观察。 [结果 ]两组经治疗后 ,PAS组症状和阳性体征较EDTA组改善明显 ,血锰水平降低较EDTA组明显 (P <0 0 1) ,但尿锰排出较ED TA组低 (P <0 0 5 ) ,PAS Na治疗后 4例患者脑脊液锰含量相当于治疗前脑脊液锰含量的 1 0～ 2 7 5倍 ,而血、尿锰均较治疗前明显下降。 [结论 ]PAS Na有明显的驱锰作用 ,脑脊液锰含量可作为慢性锰中毒生物监测的客观指标之一。Objective] To appraise the therapeutic effect of PAS Na on chronic manganism. [Methods] According to GB3232 82, 52 patients were diagnosed as manganese observed objects,light and heavy manganism,and then the clinical data of patients were retrospectively analysed by two groups,one was given PAS Na,the other was given EDTA Na 2Ca to investigate the therapeutic effect. [Results] After treated,in PAS Na group,systems and positive signs were more improved than in the another group,the level of blood manganese was apparent lower ( P <0 01),but the output of urinary manganese was lower ( P <0 05). In four patients of PAS Na group the cerebrospinal manganese was 1 0～27 5 times higher after treated,but the blood manganese and urinary manganese were significantly lower after treated. [Conclusions] PAS Na can obviously eject manganese;the concentration of cerebrospinal manganese is an objective biomonitoring index in chronic manganism.

关 键 词：锰中毒 对氨基水杨酸钠 驱锰疗效 治疗 

分 类 号：R135.1[医药卫生—劳动卫生]