不动杆菌致医院获得性肺炎的临床特点及耐药性分析  

Analysis on drug resistance and clinical speciality of nosocomial pheumonia caused by acinetobacter

作　　者：周锦云[1] 王梦义[2] 张宏[2] 司进[3] 

机构地区：[1]天津市第四中心医院,300140 [2]天津医科大学代谢病医院 [3]天津医科大学第二临床医学院

出　　处：《医学文选》2001年第1期6-7,共2页Anthology of Medicine

摘　　要：目的　了解不动杆菌导致医院获得性肺炎的临床特点及其对临床常用抗生素的耐药性。方法　采用 Kirby-Bauer琼脂扩散法 ,按 NCCL S1993年标准判断结果 ,检测医院获得性肺炎患者痰中不动杆菌 33株。结果　 33例患者发病前均有使用一种或多种抗生素病史 ,84.85 %为 COPD,5 4.5 5 %有混合感染 ,死亡率 45 .45 %。 33株不动杆菌对氨苄西林、哌啦西林耐药率较高 (75 .76 % ,5 4.5 5 % ) ,对庆大霉素、头孢唑啉、阿米卡星、头孢哌酮、头孢三嗪耐药率为 18.18%～ 2 7.2 7% ,对氧氟沙星、环丙沙星、头孢噻肟耐药效率低于 10 %。结论　不动杆菌在医院获得性肺炎中占有重要位置 ,病情复杂 ,死亡率高。不动杆菌对多种抗生素有不同程度耐药 ,对氧氟沙星。Objective\ To find the resistance to commonly used antibiotics and the clinical speciality of nosocomial pheumonia caused by acinetobacer Methods\ 33 clinical isolates were collected from sputum of patients with nosocomial pheumonia Bacterial susceptibility testing was carried out using Kirby Bauer method Eleven different antibiotic discs were used Results\ At least one kind of antibiotic were used in all cases 28 patients were COPD,making up 84 85% 54 55%of the patients had mixed infection,the mortality was 45 45% Ofloxacin,ciprofloxacin,cefotaxime showed a very good antibacterial activity against acinetobacter,Ampicillin and piperacillin showed a quite low activity Conclusion\ Acinetobacter played an important role in nosocomial pneumonia Ofloxacin,ciprofloxacin and the third generation cepalosporins can be used for empirical treatment of the nosocomial peumonia caused by acinetobacter

关 键 词：不动杆菌 抗药性 医院获得性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]