脾虚型慢性萎缩性胃炎疗效影响因素的COX模型分析  

COX model analysis on factors of therapeutic efficacy on chronic atrophic gastritis of "Pi Xu" type

作　　者：潘从清[1] 胡利民[2] 袁红霞[2] 徐东琴[2] 高金亮[3] 

机构地区：[1]天津医科大学代谢病医院,300070 [2]天津中医学院 [3]天津市中医药研究院

出　　处：《天津医科大学学报》2001年第3期361-363,共3页Journal of Tianjin Medical University

摘　　要：目的 :分析中药治疗脾虚型慢性萎缩性胃炎疗效的影响因素。方法 :随访236例脾虚型慢性萎缩性胃炎患者应用COX危险比例模型分析疗效的影响因素。结果 :单因素分层分析结果 :年龄 (X2)、职业 (X3)、胃窦病理程度(X 11)、疗程 (X 6)、不同辨证分型对本病疗效影响显著。将20个因素全部进入COX模型 ,应用逐步上升法筛选各显著因素 ,得实际较优模型 :h(t、x)=h0(t)exp(0.5502x11-0.3247x1-0.0149x2-0.3101x20),由模型可知性别(X1)、年龄 (X 2)、胃窦病理程度 (X 11)、脾虚血瘀症 (X 20)对本病疗效影响较大。结论 :通过以上分析 。Objective: To analyze the influential factors of therapeutic effect on Chinese traditional drugs in treating chronic atrophic gastritis (CAG) of 'Pi Xu' type. Methods: 236 patients with CAG of 'Pi Xu'type were investiged with COX proportional hazard model. Results:The result from single factor fractional analysis: age(x2), profession (x3), pathologic degree on antral region of stomach (x11), course of treatment (x6) and differentiation of symptoms and signs typing had significant effect on therapeutic efficacy. The result from analysis on 20 factors by COX model: significant factors were selected by gradual ascending model, practical model was h (t, x)=ho (t) exp(0.5502x11-0.3247x1-0.0149x2-0.3101x20). Sex (x1), age (x2), pathologic degree on antral region of stomach (x11), 'Pi Xu' and deficiency of blood sign had significant action on therapeutic efficacy. Conclusion: The analysis of CAG pathophysiology characters and application of promoting blood circulation by removing blood stasis therapy are one of the important methods to improve the CAG therapy.

关 键 词：脾虚型慢性萎缩性胃炎 疗效 COX危险比例模型 治疗 

分 类 号：R259.733.2[医药卫生—中西医结合]