硝苯地平控释片对原发性高血压患者左室肥厚及血清组织纤维化指标的影响  

Effect of Adalat GITS on left ventricular hypertrophy and serum fibrotic markers in hypertensive patients

作　　者：胡晓晟[1] 张美媛[2] 陈君柱[1] 胡志强[3] 邱原刚[1] 

机构地区：[1]浙江大学医学院附属第一医院心内科,杭州310003 [2]海宁市第三医院内科 [3]浙江大学医学院附属第一医院超声诊断科

出　　处：《临床心血管病杂志》2001年第10期445-447,共3页Journal of Clinical Cardiology

摘　　要：目的 :观测硝苯地平控释片对原发性高血压 ( EH)患者左室肥厚 ( L VH)和心肌纤维化的影响。方法 :3 4例经超声心动图检查确诊为 EH伴 L VH患者 ,予硝苯地平控释片 3 0～ 60 mg/ d治疗 2 4周。治疗前、治疗后 12周和 2 4周分别测算左室重量指数 ( L VMI) ,测定血清 型前胶原 ( PC )、透明质酸 ( HA )、层粘蛋白 ( L N)、 型胶原 ( C )和转移生长因子β1 ( TGF-β1 )。并与对照组 ( 2 8例 )比较。结果 :硝苯地平控释片治疗 12周 ,L VMI从14 7.5± 18.6降至 13 1.7± 2 0 .4 ( P <0 .0 5 ) ,治疗 2 4周 ,L VMI改善更明显 ( P <0 .0 1)。除血清 C 外 ,PC 、HA、L N在 EH伴 L VH组均高于对照组 ,治疗 2 4周 ,PC 、L N下降明显 ( P<0 .0 1)。治疗前、后明显降低 TGF-β1 ( P <0 .0 1)。PC 、L N与 L VMI、TGF- β1 均呈正相关 ( P <0 .0 5 )。结论 :硝苯地平控释片长期治疗能减轻 EH患者 L VH。Objective:To determine the effect of Adalat GITS on left ventricular hypertropy and myocardial fibrosis.Method: Thirty four hypertensive patients with left ventricular hypertrophy (LVH) were treated with Adalt GITS for 24 weeks. Left ventricular mass index (LVMI), serum level of procollagen type Ⅲ(PCⅢ), laminin (LN), hyaluronic acid (HA), collagen type Ⅳ(CIV) and transforming growth factor β 1 (TGF β 1) were measured before and after 12, 24 week treatment. These parameters were also measured in 28 healthy subjects.Result: LVMI, serum level of PCⅢ and LN were lowered significantly in 34 hypertensive patients with 24 week treatment (P< 0.01 ). Serum level of TGF β 1 was also decreased markedly during 24 week treatment by Adalat GITS. Serum level of PCⅢ, LN were positively correlated with LVMI and TGF β 1 in hypertensive patients. Conclusion: Adalat GITS can reduce LVH as well as myocardial fibrosis in hypertensive patients.

关 键 词：原发性高血压 硝苯地平控制释片 左心室肥厚 纤维变性 EH LVH 

分 类 号：R544.1[医药卫生—心血管疾病] R541.9[医药卫生—内科学]