莪术的质量研究  

STUDY ON THE QUALITY OF RHIZOMA CURCUMAE

作　　者：王琰[1] 王慕邹[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《药学学报》2001年第11期849-853,共5页Acta Pharmaceutica Sinica

基　　金：国家九五攻关专项基金资助项目 ( 9690 30 2 0 2 )

摘　　要：目的　研究莪术的化学成分及其药理作用 ,寻找与中医用药功能主治相吻合的有效成分 ,并比较不同品种及产地的莪术在质量上的差异。方法　用柱色谱的方法分离提取单体化合物 ,确定结构 ,并分别进行药效学实验 ,确定有效成分 ,通过HPLC比较不同品种中有效成分含量 ,评价莪术的质量。结果　从中提取分离了 7个单体化合物 ,姜黄素显出较强的药理活性 ,但在广西莪术中未检出 ;吉马酮的含量较高 ,有一定的活性 ,在 3种莪术中均有分布 ;挥发油作为一个提取部位 ,显出较强的药理活性。结论　莪术中姜黄素是主要有效成分之一 ,吉马酮可选作特征成分 ,挥发油可为有效部位。莪术不同品种所含成分有显著差异 ,以此 3个指标作为莪术质量评价指标。AIM To study the chemical constituents of Rhizoma Curcumae and their pharmacological action to find out the effective components. The effective components should agree with the main curative effect in Chinese traditional medicine. Based on the contents of effective components, evaluation for the quality of Rhizoma Curcumae was investigated. METHODS A method of column chromatography was used to separate the components. After identification, the effective components were confirmed by several pharmacological tests. An HPLC method was developed for the determination of the effective components. RESULTS Seven compounds were isolated from Rhizoma Curcumae. They are curcumin, demethoxycurcumin, bisdemethoxycurcumin, curcumol, curdione, isocurcumenol and germacrone. Curcumin showed strong pharmacological action but was not detected in Curcuma kwangsiensis . Germacrone showed weaker pharmacological action and was found in all species of Rhizoma Curcumae. As an extract part, the volatile matter showed stronger action. CONCLUSION Curcumin and germacrone were selected as the effective components and the volatile matter also as the effective part. Considerable difference of the contents was detected in different species of Rhizoma Curcumae.

关 键 词：中药 莪术 有效成分 药理活性 质量 研究 高效液相色谱法 

分 类 号：R282.71[医药卫生—中药学]