治疗性疫苗治疗慢性乙型肝炎的效果  

Effect of therapeutic vaccine in treating chronic hepatitis B

作　　者：邓见廷[1] 徐龙[1] 涂相林[1] 康海[1] 吴国伟[1] 汤红萍[1] 吴林[1] 

机构地区：[1]江西省南昌市第九医院,330002

出　　处：《现代实用医学》2001年第9期439-441,共3页Modern Practical Medicine

摘　　要：目的　探讨治疗性疫苗治疗慢性乙型肝炎 (慢乙肝 )的疗效。　方法　 3 0例慢乙肝患者为研究组 ,采用治疗性疫苗 (基因重组乙肝疫菌 3 0 μg联合佐剂 1ml)治疗 ,皮下注射 ,每月 1次 ,疗程 6个月 ;2 8例慢乙肝患者作为对照组 ,给予常规的护肝等治疗而不使用抗病毒及免疫调节药物。　结果　研究组治疗后血清BHsAg、HBeAg、HBVDNA阴转率分别为 6.7%、3 7.5 %、42 .1 %,对照组分别为 0 %、9.5 %、1 1 .1 %,研究组治疗后血清HBeAg、HBVDNA阴转率明显高于对照组 (P <0 .0 5 )。研究组治疗后血清HBsAg、HBeAgS/N值下降大于 3 0 %例数分别为 2 6.7%(8/3 0 )、41 .7%(1 0 /2 4) ,HBVDNA下降大于5 0 %例数为 68.4%(1 3 /1 9) ;治疗前后血清HBeAgS/N值分别为 2 9.85± 1 2 .41和 1 9.65± 1 4.2 6(P <0 .0 5 ) ;治疗前后血清HBsAgS/N值分别为 3 3 .0 9± 8.98和 2 9.74± 1 0 .69(P >0 .0 5 ) ;研究组治疗后肝功能复常率为 73 .3 %(2 2 /3 0 )。　结论　大剂量乙肝疫苗联合佐剂治疗能明显降低血清HBeAg、HBsAg(S/N)及HBVDNA值 ,达到减少HBV复制、清除HBV的目标 ,并能增加抗 HBs的产生。Objective To explore the curative effect of therapeutic vaccine in treatment for chronic hepatitis B(CHB). Methods 58 cases of chronic hepatitis B were divided randomly into two groups.The research group contained 30 cases which treated with therapeutic vaccine (gene recombination hepatitis B vaccine 30μg uniting adjuvant 1ml),hypodermic injection,once a month for six months. 28 cases were taken as a control group which received routine liver equalcure protection without using antivirus and immunomodulating drugs. Results The negative rates of serum HBsAg and HBeAg, HBV DNA of the research group was 6.7%, 37.5 % and 42.1% respectively, and those of the control group was 0%, 9.5% and 11.1%,respectively. Among those,the negative rate of serum HBeAg and HBV DNA between two groups has significant defference(P< 0.05 ).In the research group those of serum HBsAg, HBeAg S/N titre fell over 30% was 26.7% (8/30) and 41.7 % (10/24) respectively,and,the cases of HBV DNA tell over 50% falls hold 68.4% (13/19);pre and post therapy HBeAg S/N titre was 29.85±12.41 and 19.65±14.26 respectively(P<0.05);pre and post therapy HBsAg S/N titre 33.09±8.98 and 29.74±10.69,respectively(P>0.05).The recovery rate of liver function in research group was 73.3%(22/30). Conclusion High dose hepatitis B vaccine combined with adjuvant treatment CHB (light degree) has definite curative effect and reduce serum HBeAg, HBsAg (S/N) and HBV DNA titre,so as to achieve decreasing HBV replication,purging HBV and increasing anti HBs production.

关 键 词：慢性乙型肝炎 乙型肝炎疫苗 HBV 疫苗治疗 

分 类 号：R512.62[医药卫生—内科学]