缓释异搏定对高血压病患者交感神经张力的影响  

Effects of isoptin-SR to the sympathetic nervous system activity in essential hypertension

作　　者：张瑞军 孙宁玲[2] 杨璇 唐淑华 刘峰 

机构地区：[1]齐鲁石化公司中心医院心内科,山东省淄博市255400 [2]北京医科大学人民医院心内科

出　　处：《临床内科杂志》2001年第4期272-274,共3页Journal of Clinical Internal Medicine

摘　　要：目的　通过握力试验方法激发高血压病患者的交感神经活性 ,观察缓释异搏定和氨氯地平对交感神经活性的影响。方法　将 16 0例高血压患者随机分为两组 ,采用握力试验方法 ,测量药物治疗前、后血压和心率变化。结果　治疗前两组最大握力试验时血压及心率上升百分比比较差异无显著性 ,治疗后两组最大握力试验时血压上升百分比 (SBP/DBP) :缓释异搏定组为 7.8% / 7.3 % ,氨氯地平组为 13 .7% / 12 .9% ,两组比较差异有显著性 (P <0 .0 5 ) ,两组心率增加分别为 5 .3 %和 11.6 % ,两组比较差异有显著性 (P <0 .0 5 )。结论　钙离子拮抗剂缓释异搏定能明显降低高血压病患者的交感活性 。Objective To evaluate the effects of isoptin SR and amlodipine on sympathetic nervous system(SNS) in patients with hypertension. Methods One hundred and sixty cases were randomly alloted into two groups: group A(80 cases) accepted isoptin SR(240mg/d) and group B(80 cases) accepted amlodipine(5～10 mg/d).Before treatment, all patients accepted andgrip test while the SBP,DBP and HR were measured during all the periods of the experiment. After treatment for six weeks by isoptin SR or amlodipine, the handgrip test was repeated.Results Before treatment, the SBP/DBP increased 20.3%/20.4%(group A) and 20.6%/20.2%(group B) and HR increased 14.5%(group A) and 14.7%(group B) during the handgrip test. After treatment, the SBP/DBP increased 7.8%/7.3% (group A) and 13.7%/12.9% (group B),HR increased 5.3% (group A) and 11.6%(group B) .Conclusion The SNS activity of the patients with hypertension can be determined by the handgrip test. Isoptin SR can decrease the activity of SNS, then reduce the blood pressure steadily.

关 键 词：高血压 交感活性 握力试验 缓释异搏定 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]