肺部疾病患者血浆α-颗粒膜蛋白及D-二聚体测定的临床意义  

A clinical study on effects of plasma levels of a granule membrane protein and D dimer in patients with lung diseases

作　　者：杜娟[1] 邓冰[2] 董亚琼[1] 费樱[3] 

机构地区：[1]贵阳医学院附属医院呼吸内科,贵阳550004 [2]贵阳医学院预防医学系 [3]贵阳医学院附属医院放免室

出　　处：《临床内科杂志》2001年第4期287-288,共2页Journal of Clinical Internal Medicine

摘　　要：目的　探讨血小板活化、凝血非常激活与肺部疾病的关系。方法　用酶联免疫双抗体夹心法分别测定 2 5例肺心病患者、15例肺癌患者及 36例肺结核患者血浆α 颗粒膜蛋白 (GMP 14 0 )、D 二聚体浓度 ,并与 2 0例对照组的结果进行比较。结果　肺心病及肺癌患者血浆GMP 14 0、D 二聚体浓度与正常对照组比较 ,差异有非常显著性 (P <0 .0 1)。肺癌与肺心病、肺结核患者血浆GMP 14 0比较 ,差异有非常显著性 (P <0 .0 1)。肺结核患者血浆GMP 14 0、D 二聚体浓度均升高 ,但与对照组比较 ,差异无显著性 (P >0 .0 5 )。结论　血小板活化、凝血系统激活及内皮细胞损伤在肺心病。Objective To explore the clinical significance and relationship between platelet activation and enhanced coagulability and the lung diseases. Methods Plasma levels of α granule membrane protein (GMP 140) and fibrin D dimer were measured by two layer antibody sandwich enzyme linked immunosorbent assay in 25 patients with pulmonary heart disease, 15 patients with lung cancer, 36 patients with lung tuberculosis and 20 healthy people as control group. Results The differences were significant comparing the plasma levels of GMP 140 and D dimer in patients with pulmonary heart disease and lung cancer with those in control group (P<0.01). Differences were highly significant comparing the levels of GMP 140 in patients of the cancer with those in them of pulmonary heart disease and lung tuberculosis (P<0.01). The levels of GMP 140 and D dimer increased in patients with lung tuberculosis but differences were not significant (P>0.05) as compared with those in control group. Conclusion Platelet activation, enhanced coagulability and endotheliocyte damage possess important effects in the occurrence and development of pulmonary heart disease and lung cancer.

关 键 词：肺心病 肺肿瘤 肺结核 Α-颗粒膜蛋白 D-二聚体 测定 肺疾病 

分 类 号：R563[医药卫生—呼吸系统]