有偿供血员HCV、HIV和HBV感染的调查分析  

The prevalence of HCV, HIV and HBV among paid blood donors

作　　者：张永喜[1] 罗小光 桂稀恩[1] 张险峰 李毅 

机构地区：[1]武汉大学中南医院感染科,430071 [2]湖北省卫生防疫站艾滋病监测中心 [3]武汉钢铁公司第二院医院感染科

出　　处：《临床内科杂志》2001年第4期308-309,共2页Journal of Clinical Internal Medicine

摘　　要：目的　了解有偿供血员感染丙型肝炎病毒 (HCV)、艾滋病病毒 (HIV)和乙型肝炎病毒 (HBV)的情况 ,分析HCV和HIV感染对HBsAg的影响。方法　检测 2 96名供血员血清抗 HCV、抗 HIV和HBV的 5项标志物 (HBsAg、抗 HBs、HBeAg抗 HBe及抗 HBc)。 结果　 2 96例有偿供血员中 ,抗 HCV阳性 194例 ,占 6 5 .5 %。抗 HCV阳性者中 ,抗 HIV阳性为 14 5例 ,占HCV总阳性的 75 %。本组AIDS患者均死于肝外感染或肿瘤而非肝病。HCV合并HIV感染组的HB sAg阳性率为 2 .8% ,明显低于单纯HCV和单纯HIV感染者 (10 % ) ,两组比较差异有显著性 (P <0 .0 5 )。结论　在HIV高发区 ,抗 HCV阳性有偿献血员常合并HIV感染 ,是AIDS高危人群。HCV合并HIV感染 。Objective To investigate the prevalence of hepatitis C virus(HCV), human immunodeficiency virus( HIV) and hepatitis B virus(HBV) among paid blood donors and to analyze the effect of HCV and HIV on production of hepatitis B virus surface antigen(HBsAg).Methods Antibodies against hepatitis C virus (anti HCV) and human immunodeficiency virus (anti HIV), and five serum markers of hepatitis B virus (HBVM) were determined by ELISA in 296 paid blood donors. Results One hundred and ninety four samples from 296 donors(65.5%) were positive for anti HCV . In the donors who were infected by HCV, 145 samples (75%) were positive for anti HIV. Thirteen patients with AIDS died. The causes of death were infections and/or carcinoma,but not liver disease. The positive rate of HBsAg(2.8%) was lower among the donors infected with both HCV and HIV than that of the donors infected with HCV or HIV alone (10%)(P<0.05). Conclusion In high epidemic areas of HIV blood donors with HCV infection are at high risk of HIV infection. Superinfection of HCV and HIV may interfere the production of HBsAg.

关 键 词：丙型肝炎病毒 乙型肝炎病毒 艾滋病毒 调查分析 供血员 

分 类 号：R181.81[医药卫生—流行病学]