不同血钾水平时索他洛尔对在体跨室壁心肌复极不均一性的影响  

Effect of Sotalol on Myocardial Repolarization Heterogeneity across the Left Ventricular Wall in vivo in Different Serumal Potassium Levels

作　　者：张存泰[1] 李运田[1] 陆再英 吴杰[1] 王晨[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院心内科,武汉430030

出　　处：《同济医科大学学报》2001年第1期32-35,共4页Acta Universitatis Medicinae Tongji

基　　金：卫生部科研基金资助项目 (No.98- 2 - 0 95 )

摘　　要：为了观察正常血钾和低血钾时索他洛尔对在体跨室壁心肌复极不均一性的影响 ,探讨索他洛尔致室性心律失常的机制。 2 4只兔随机分为两组 ,正常血钾组 (12只 )和低血钾组 (12只 ) ,分别静注索他洛尔 1.0 m g/ kg,3.0 mg/kg;同步记录兔左室心外膜心肌 (Epi)、中层心肌 (Mid)和心内膜心肌 (Endo)的单相动作电位 (MAP) ,研究发现低钾时与血钾正常时相比 ,索他洛尔增加跨室壁心肌复极离散度 (TDR)的作用更明显 ;更易引起 Mid发生早期后除极 (EAD) ;低血钾组尖端扭转性室速 (Td P)The effect of sotalol on repolarization heterogeneity across the left ventricular wall in normal serum potassium and hypopotassemia was investigated and the relationship between the repolarization heterogeneity and arrhythmia explored. Twenty four rabbits were randomly divided into two groups ( n =12 in each group): a group with normal serum potassium and other group with hypopotassemia. In the two groups, after intravenous injection of different doses (1.0 mg/kg, 3.0 mg/kg) of sotalol into the rabbits, monophasic action potential (MAP) of epicardium (Epi), midmyocardium (Mid) and endocardium (Endo) were simultaneously recorded at the left ventricular myocardium. The results showed that the sotalol increased transmural dispersion of repolarrization (TDR) more obviously in hypopotassemia group than in normal serum potassium group. The early after depolarization in Mid was more easily recorded and the incidence of torsade de points was higher in hypopotassemia group.

关 键 词：单相动作电位 复极不均一性 索他洛尔 低血钾 尖端扭转性室速 

分 类 号：R972[医药卫生—药品] R5[医药卫生—药学]