三苯氧胺、米非司酮并用米索前列醇抗早孕效果观察  

Comparative analysis for the effect of terminating early pregnancy between tamoxifen and mifepristone both based on misoprostol

作　　者：霍琰[1] 于风华[1] 王秀丽[1] 王树松 梅祖敏[1] 

机构地区：[1]河北省人民医院妇产科,石家庄市050051 [2]河北省计划生育科研

出　　处：《河北医药》2001年第11期810-812,共3页Hebei Medical Journal

基　　金：河北省计划生育委员会 2 0 0 0年资助课题

摘　　要：目的　观察三苯氧胺并米索前列醇 (米索 )抗早孕的临床效果 ,同时与米非司酮合并米索作临床随机对比观察 ,评价其可行性 ,为临床提供一种新的抗早孕方法。方法　 1 97例妊娠≤ 56d的妇女 ,按随机表分为两组。结果　研究组完全流产 83例 (84.7% ) ,对照组 90例 (90 .9% ) ,两组比较差异无显著性 ,P >0 .0 5 ;研究组阴道出血时间 (1 0 .3± 5 .1 )d,较对照组 (1 4 .0± 6 .4)d明显缩短 ,1 5d内阴道出血停止者 ,研究组 64例 (77.1 % ) ,对照组 48例 (53.3 % ) ,两组比较差异非常显著 ,P <0 .0 1 :研究组服三苯氧胺后大多数早孕反应未见明显加重 ,而对照组服米非司酮后大多数早孕反应症状进一步加重 ,副反应明显增加 (P <0 .0 1 )。结论　三苯氧胺并米索能有效终止早孕 ,具有抗早孕作用 ,且药物副反应小 ,价格便宜 ,流产后出血时间短 ,完全流产率与米非司酮接近 。Objective To evaluate the clinical effect of tamoxifen with misoprotol on terminating early pregnancy and compare it with that of mifepristone with misoprostol.Methods One hundred and ninety seven pregnancy women (≤56 d) were randomly divided into two groups,98 cases in experiment group received tamoxifen 20 mg daily for 4 days,with a total dosage of 80 mg,then misoprostol 800 mg was placed into the vagina on the fifth and sixth day.99 cases of control group received mifepristone 50 mg daily for 3 days,with a total dosage of 150 mg,besides,misoprostol 600 μg was taken at 8 am on the fourth day.Results The complete abortion rate,incomplete abortion rate and failure rate in experiment group were 84.7%(83/98),7.1%(7/98) and 8.2%(8/98) respectively,compared with 90.9%(90/99),6.1%(6/99) and 3.0%(3/99) in control group,there were no significant differences between two groups  (P>0.05). The everage days of vaginal bleeding were 10.3±5.1 in experiment group versus 14.0±6.4 in control group,there were significant differences between two groups (P<0.01).Conclusion Tamoxifen with misoprostol could effectively terminate early pregnancy and could be used as one of the antigestational methods.

关 键 词：三苯氧胺 米非司酮 米索前列醇 抗早孕 临床效果 药物流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学] R979.22