氯化饮水有机提取物和MX对大鼠脂质过氧化作用影响的研究  

Study on the Influence of Chlorinated Drinking Water Extracts and MX on Lipid Peroxidation in Rats

作　　者：李晓燕[1] 陈丹[1] 谢虹[1] 陈秀娜[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院环境卫生学教研室,武汉430030

出　　处：《同济医科大学学报》2001年第5期419-421,共3页Acta Universitatis Medicinae Tongji

基　　金：国家"九五"科技攻关资助项目 ( No.969110 70 2 )

摘　　要：采用 Wistar大鼠灌胃染毒方法 ,观察氯化饮水有机提取物和氯化副产物 3 -氯 - 4 - (二氯甲基 ) - 5 -羟基 - 2 ( 5氢 ) -呋喃酮 (简称 MX)对大鼠组织脂质过氧化作用 ( L PO)及谷胱甘肽 ( GSH)含量的影响。结果表明 ,不同浓度的氯化饮水有机提取物均可使大鼠肝脏、肾脏和睾丸中脂质过氧化产物——丙二醛 ( MDA)含量明显增加 ,肝脏丙二醛的含量随浓度的增高而增高 ,GSH随浓度的增高而下降。MX对染毒大鼠组织中丙二醛和 GSH含量无明显影响。The chlorinated drinking water (CDW) extracts and 3 chloro 4-(dichloromethyl) 5 hydroxy-2(5H)-Furanone (MX) were administered to Wistar rats by gavage to study the influence of CDW and MX on the lipidperoxidation (LPO) and glutathion (GSH). The results showed that the levels of malondialdehyde (MDA) were increased in the liver, kidney and testicle of rats exposed to the all concentrations of CDW extracts. In the liver of rats MDA was significantly enhanced and GSH decreased with the increase of the concentrations of CDW. No significant influence of MX on the levels of MDA and GSH was observed in the animals tested.

关 键 词：氯化饮水 有机提取物 3-氯-4-(二氯甲基)-5-羟基-2(5氢)-呋喃酮 脂质过氧化 谷胱甘肽 MX 

分 类 号：R123.5[医药卫生—环境卫生学]