肠神经元发育异常临床分析  

A Clinical Analysis on Intestinal Neuronal Dysplasia

作　　者：翁一珍[1] 李娜萍[2] 周学锋[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院小儿外科,武汉430030 [2]华中科技大学同济医学院基础医学院病理学教研室,武汉430030

出　　处：《同济医科大学学报》2001年第5期460-461,共2页Acta Universitatis Medicinae Tongji

摘　　要：为探讨肠神经元发育异常 ( INDB)的临床特点、诊断和治疗。同济医院自 1997年 1月至 1999年 6月共收治 15例INDB患者 ,其中单纯 INDB9例 ,合并先天性巨结肠 ( HD) 6例 ;诊断依据 :1临床症状便秘 ;2钡灌肠 ;3测压 ;4组化 ;5病检。治疗 :根治术 13例 ,回肠造瘘 1例 ,直肠内括约肌部分切除 1例。对 12例进行随访 ,时间 6个月至 2年 6个月 ,平均 1年 6个月 ,11例效果好 (占 91% )。表明 INDB临床症状和 HD相似 ,而病理与之截然不同 ,因此正确认识此病极为重要。In order to study the clinical presentations, diagnosis and treatment of intestinal neuronal dysplasia (IND) in child, 15 children with IND B were admitted to Tongji Hospital from Jan. 1997 to June 1999. Of these children, 9 were diagnosed as having simple IND and 6 having IND associated with Hischsprung's Disease (HD). Diagnostic criteria of IND were as follows: (1) Clinical symptom of constipation; (2) X-ray barium enema; (3) Rectoanal manometry; (4) AchE histochemistry staining and (5) Histopathological study for resection specimens. Radical operation was performed in 13 cases, ileoostomy in 1, partial sphincterectomy in 1. Twelve of the patients were followed-up for 6 to 30 months (average 18 months), with an excellent result in 11 cases (91 %). It was indicated that the symptoms of IND were similar to that of HD, but there were differences in histopathology between IND and HD.

关 键 词：肠神经元发育异常 诊断 外科手术 儿童 临床分析 

分 类 号：R726.2[医药卫生—儿科] R726.1[医药卫生—临床医学]