血管内皮细胞生长因子及其受体KDR/flk-1对造血起重要调节作用(英文)  

Vascular Endothelial Growth Factor and Its Receptor KDR/flk-1 Play Important Roles in Hematopoiesis

作　　者：洪登礼[1] 张瑶珍[1] PIACIBELLO Wand AGLIETTA Massimo 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院血液内科,武汉430030 [2]意大利都灵大学医学院生物医学科学和人类肿瘤学系,都灵10060

出　　处：《中国实验血液学杂志》2001年第3期268-272,共5页Journal of Experimental Hematology

摘　　要：现在普遍认为造血细胞和内皮细胞来源于同一群前体细胞 ,即成血管细胞 (hemangioblast) ,但是这群前体细胞至今还没有得到证实。血管内皮细胞生长因子 (vascularendothelialgrowthfactor,VEGF)及其受体KDR/flk 1是内皮细胞增殖和血管形成的主要调节因子。最近一些实验结果表明 ,VEGF及其受体KDR/flk 1在胚胎和出生后造血中起重要调节作用 ,但确切的作用和机制还不清楚。一些最近发展起来的细胞和分子生物学技术将有利于证实成血管细胞的存在 ,有利于探讨成血管细胞的生物学性质和VEGF及其受体KDR/flkIt is widely accepted that hematopoietic and endothelial cell lineages are initiated from the same precursor cells (named as hemangioblast), although hemangioblast has not been proved. Vascular endothelial growth factor (VEGF) and its receptor KDR/flk-1 is a prime regulator of endothelial cell proliferation, angiogenesis, vasculogenesis and vascular permeability. It is speculated that VEGF and its receptor KDR/flk-1 may also play an important role in embryonic and postnatal hematopoiesis. But the exact role and mechanism are not well known. Some latest developed cellular and molecular techniques can be used to prove the existence of hemangioblast and to investigate its biologic feature and the effect of VEGF and receptor KDR/flk-1 on its biologic feature.

关 键 词：血管内皮细胞生长因子 KDR/FLK-1 成血管细胞 VEGF 造血 血管发生 

分 类 号：R331.2[医药卫生—人体生理学]