5,6-二甲基苯并咪唑的合成工艺改进  

Improved Technology for Synthesis of 5,6-Dimethylbenzimidazole

作　　者：苏砚溪[1] 杨纪清[1] 

机构地区：[1]河北师范大学化学系,河北石家庄050091

出　　处：《精细化工》2001年第2期76-77,97,共3页Fine Chemicals

摘　　要：以 3,4 二甲基苯胺为母体 ,合成了 5 ,6 二甲基苯并咪唑。产品收率达 41%。在乙酰化、硝化反应中引入了 1,2 二氯乙烷溶剂。用正交实验确定了最佳原料配比 :n(3,4 二甲基苯胺 )∶n(醋酐 )∶n(硫酸 ) =1 0 0∶1 30∶1 13。改进后 ,每mol母体的醋酐用量由 30 3 0g减少至 132 6g ,浓硫酸用量由 30 3 8g减少至 110 74g。Dimethylbenzimidazole was synthesized with 3,4 dimethylaniline as raw material.The yield of product was over 41%.In the reaction of acetylation and nitration 1,2 dichloroethane was used as solvent.The optimal molar ratio of reactants was 3,4 dimethylaniline∶acetic anhydride∶sulfuric acid=1 00∶1 30∶1 13.In this improved technology,amount of acetic anhydride was reduced from 303 g to 132 6 g,and amount of sulfuric acid was reduced from 303.8g to 110 74 g for each mole of 3,4 dimethylaniline.

关 键 词：5 6-二甲基苯并咪唑 3 4-二甲基苯胺 乙酰化 合成 工艺改进 

分 类 号：TQ252.3[化学工程—有机化工]