胰岛素治疗对2型糖尿病病人胰岛β细胞功能的影响  

OBSEVATION OF INSULIN TREATMENT FOR TYPE 2 DIABETES MELLITUS

作　　者：曲庚汝[1] 王海燕[1] 郭连州 李利[1] 杨乃龙[1] 

机构地区：[1]青岛海慈医院内分泌科,青岛266033 [2]山东省荣城市第二人民医院

出　　处：《齐鲁医学杂志》2001年第2期115-116,共2页Medical Journal of Qilu

摘　　要：①目的　探讨胰岛素治疗对 2型糖尿病病人胰岛 β细胞功能的影响。 ②方法　将 10 0例病程超过10年 ,血糖控制不良的 2型糖尿病病人 ,随机分为两组 ,A组给予常规治疗 ,B组给予胰岛素强化治疗 ,治疗前后应用放免法测C肽。③结果　B组病人治疗后血C肽基础值及高峰值均明显高于治疗前 (t=2 .34,2 .38,P <0 .0 5 ) ,A组病人治疗后血C肽基础值及高峰值较治疗前虽有增加 ,但差异无统计学意义 (t =1.73 ,1.84,P >0 .0 5 )。B组治疗前后C肽变化较A组明显 (t=2 .2 3 ,2 .13 ,P <0 .0 5 )。④结论　病程超过 10年的 2型糖尿病病人及时采用胰岛素治疗有利于保护胰岛 β细胞功能 。Objective To study the effect of insulin treatment on the function of islet in type 2 diabetes mellitus. Methods 100 type 2 diabetic patients with a history of more than 10 years and with high blood glucose were randomly divided into Group A and Group B. In Group A, the patients were given regular oral hypoglycemic. In Group B, the patients were given insulin intensive treatment. A measurement of C-peptide was carried out before and after the treatment.\ Results In Group B ,the C-peptide level was higher after treatment than that before the treatment (t=2.34,2.38,P<0.05),while in Group A ,the C-peptide levels, before and after the treatment ,were not different significantly. \ Conclusion Treatment of type 2 diabetes mellitus, with a history of more than 10 years ,with insulin in time could diminish glucose toxicity and protect the function of islet.

关 键 词：Ⅱ型糖尿病 C肽 胰岛素 Β细胞 药物治疗 

分 类 号：R587.1[医药卫生—内分泌]