氯化饮用水有机提取物对睾丸支持细胞的毒性效应研究  

Toxic Effect of Organic Extracts From Chlorinated Drinking Water on Sertoli Cells of Testis in Rats.

作　　者：田怀军[1] 吴德生[2] 陶锐[3] 

机构地区：[1]西南师范大学生命科学学院,重庆400715 [2]四川大学华西医科大学公共卫生学院 [3]成都市卫生防疫站

出　　处：《环境与健康杂志》2001年第3期146-147,189,共3页Journal of Environment and Health

基　　金：成都市卫生局科技基金资助项目 (成卫 1 997- 31 )

摘　　要：目的　探讨氯化饮用水有机污染物对人类生殖健康的潜在危害。方法　采用固相萃取技术富集水中有机物 ,应用大鼠睾丸支持细胞与生精细胞共培养系统对某市氯化饮用水有机提取物的生殖毒性进行了研究。结果　有机提取物对生精细胞脱落率未产生明显影响 ,但可刺激支持细胞分泌乳酸。Objective To explore the potential hazards of organic pollutants in chlorinated drinking water on human reproduction Methods The reproductive toxicity of the organic pollutants extracted by solid phase extraction technique from chlorinated drinking water in a city,was determined by the co culture of sertoli cells and spermatogenic cells Results No significant variation of the rate of detached spermatogenic cells was noticed compared with the control rats The organic extracts stimulated the secretion of lactate from sertoli cells of testis in rats Conclusion The organic extracts of chlorinated drinking water revealed potential reproductive toxicity

关 键 词：饮用水 有机化合物 生殖毒性 支持细胞 氯化消毒 睾丸 人体危害 

分 类 号：R994.6[医药卫生—毒理学] R123.6[医药卫生—药学]