5种抗精神病药物的毛细管区带电泳分析  

Analysis of Five Antipsychotic Drugs by Capillary Zone Electrophoresis

作　　者：胡琴[1] 车宝泉[1] 田颂九[2] 张亮[3] 

机构地区：[1]北京市药品检验所,北京100035 [2]中国药品生物制品检定所,北京100050 [3]中国药科大学,南京210009

出　　处：《药物分析杂志》2001年第6期412-415,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:用毛细管区带电泳法同时分离分析5种抗精神病药物。方法:采用未涂层石英毛细管柱（50μm×53cm,有效分离长度为47.5cm）,以150mmol·L-1乙酸钠（用磷酸调pH为2.7）为运行缓冲液,电迁移法进样（10kV,10s）,运行电压为18kV,检测波长为254nm。结果:方法分离效率高,精密度较好,所选浓度范围内线性关系良好,r值均大于0.999。 结论:方法简单可靠,分析时间短,可同时分离分析5种抗精神病药物。Objective: To establish a method for the simultaneous determination of five antipsychotic drugs by capillary zone electrophoresis. Methods: The separation was performed on a fused - silica capillary of 50 μm × 53 cm (47.5 cm of effective length) , a running buffer containing 150 mmol·L-1 sodium acetate (pH was adjusted to 2.7 with phosphoricacid) was used . Samples were injected by electrophoretic mode (10 kV, 10s). The applied voltage was 18 kV and the detection wavelength was set to 254 nm. Results: The method was efficient and has good reproducibility and linearity ( r > 0.999 for all analytes) . Conclusion: The method is simple, quick and reliable.

关 键 词：毛细管区带电泳 抗精神病药物 奥氮平 哌泊噻嗪 盐酸氯丙嗪 盐酸氟奋乃静 奋乃静 

分 类 号：R971.4[医药卫生—药品] R927[医药卫生—药学]