支气管哮喘患者心率变异性的观察  

A study of heart rate variability in asthma

作　　者：杜坚[1] 何九龙[2] 王永东[2] 蔡映云[3] 

机构地区：[1]江苏省大丰市人民医院呼吸科,224100 [2]江苏省大丰市人民医院心内科,224100 [3]复旦大学附属中山医院肺科

出　　处：《中华结核和呼吸杂志》2001年第12期744-745,共2页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的　观察支气管哮喘患者心率变异性 ,以了解其自主神经功能的变化。方法　对 6 9例年轻男性非急性发作期支气管哮喘患者 (哮喘组 ,轻度、中度和重度各 2 3例 )和 2 3名健康对照者(对照组 )作前瞻性对照研究 ,记录支气管哮喘患者和健康对照者的 2 4h动态心电图 ,作时域和频域分析。结果　反映迷走神经张力的高频 (HF)和相邻心搏的R R间期之差 >5 0ms的心搏数 (NN5 0 )计数占总R R间期的百分比 (pNN5 0 ) ,支气管哮喘患者与对照组比较 ,差异有显著性 (P <0 0 1) ;而主要反映交感神经张力的低频 (LF)、每 5min正常R R间期标准差的平均值 (SDANN) ,支气管哮喘患者与健康对照组比较 ,差异也有显著性 (P <0 0 1) ,且重度支气管哮喘患者的变化更为显著。Objective To study the changes of autonomic nervous function in the young adult with asthma through the heart rate variability(HRV).Methods Two groups of young adults, 23 healthy volunteers and 69 asthmatic young adults were divided into three groups according to the severity of asthma. Twenty-four hours Holter monitored and heart rate variability analysed. Results The HF and pNN50 that showed the vagal tone in asthma subjects increased as compared with the normal group, while the LF and SDANN that mainly showed the sympathetic tone decreased(P<0.01). These values were remarkable in the severe asthma group (P<0.01).Conclusion Even in mormal condition when patients are free of asthmatic attack, autonomic nervous function of asthmatics differ from that of normal young adults.

关 键 词：支气管哮喘 心率变异性 自主神经功能 心电图 

分 类 号：R562.25[医药卫生—呼吸系统]