锌缺乏对孕鼠及其胎鼠体内元素分布的影响  

Effects of zinc deficiency on the distribution of elements in the tissue of pregnant rats and their fetuses

作　　者：赵长峰[1] 杨洪旗[1] 姜会敏[1] 韩雪梅[2] 

机构地区：[1]山东医科大学公共卫生学院,济南250012 [2]济南市自来水公司职工医院

出　　处：《卫生研究》2001年第5期277-279,共3页Journal of Hygiene Research

基　　金：山东省自然科学基金资助课题

摘　　要：为了解锌缺乏对妊娠大鼠及胎鼠体内元素分布的影响 ,将Wistar妊娠大鼠分为缺锌组、对喂组、补锌组和对照组 ,分别喂饲缺锌 (0 7mg kg)和正常锌 (10 0mg kg)饲料 ,在妊娠第 2 1天时处死孕鼠 ,取其血液、肝、脾、肾、胎盘和胎鼠 ,用原子吸收分光光度法测定锌、铜、铁、锰、钙含量。结果表明 ,缺锌组孕鼠各组织中锌和其他元素含量均显著低于补锌组和对照组 ;而且其血液、肝、脾、肾脏中铜、铁、锰含量显著低于对喂组 ,说明锌和其他元素在肠道吸收和组织分布方面存在协同关系 ,锌缺乏所致的动物摄食量减少不是引起组织中元素含量降低的主要原因。缺锌组胎盘中铁和胎鼠中铁、钙含量则显著高于其他三组 ,反映了锌与铁元素在胎盘可能存在竞争性转运。提示锌缺乏的母体和胎儿各元素在组织中分布不一致。The influence of zinc(Zn) deficiency on the distribution of elements in tissues of pregnant rats and their fetuses was investigated. Pregnant Wistar rats were divided into zinc deficiency (ZD), pair fed(PF), zinc supplement (ZS) and control (C) groups. ZD rats were fed for 21 days a zinc deficient (0 7 mg/kg) diet and other rats were fed a similar diet supplemented with zinc (100 mg /kg). On the 21st day of gestation, blood was drawn from heart, laparotomy was performed, and liver, spleen, kidney, placentas, fetuses were removed for analysing on zinc, copper (Cu), iron (Fe), manganese (Mn) and calcium (Ca). The results showed that the element levels in blood, organs and fetuses from ZD rats were significantly lower than those from ZS and C rats. Furthermore, the levels of Cu, Fe, Mn in blood, liver, spleen, kidney of ZD rats were significantly lower than those of PF rats. It suggests that there are some coordination relationships in intestinal absorption and tissue distribution between Zn and other elements, and the decrease of elements in the body does not mainly result from the reduction of dietary intake caused by zinc deficiency. The Fe content in placentas and Fe, Ca content in fetuses of ZD rats showed a significant increase as compared with those of rats in other groups. There may be a competitive mechanism on the transportation of Zn and Fe in the placenta of rats. In brief, the distribution of minerals in maternal tissues induced by zinc deficiency might be different from those in fetuses.

关 键 词：锌缺乏 妊娠大鼠 元素分布 

分 类 号：Q581[生物学—生物化学] R591.1[医药卫生—内科学]