糖尿病多形核白细胞吞噬功能的改变  

Changes in Phagocytosis of PMNLs in Diabetes Patients

作　　者：沈飒[1] 左静南[1] 蒋更如[1] 苏青[1] 刘秀英[1] 

机构地区：[1]上海第二医科大学新华医院内分泌科,上海200092

出　　处：《上海第二医科大学学报》2001年第5期414-416,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的研究正常人及糖尿病患者多形核白细胞 (polymorphonuclearleukocytes ,PMNLs)吞噬功能的改变及钙通道阻滞剂对其的影响。　方法应用过氧化氢释放法测定白细胞吞噬功能 ,同时研究PMNLs细胞外不同浓度糖环境及钙通道阻滞剂对细胞吞噬功能的影响。　结果糖尿病患者的PMNLs吞噬功能较正常人低下。体外培养基葡萄糖浓度越高 ,吞噬功能越差 ,硝苯啶可明显改善糖尿病患者PMNLs的吞噬功能。　结论推测葡萄糖可能是通过激活L型钙通道引起细胞内游离钙浓度升高 ,从而影响吞噬功能 ,而硝苯啶可阻断该通道 ,恢复吞噬功能。Objective To study the function of phagocytosis of polymorphonuclear leukocytes (PMNLs) in diabetes patients and healthy subjects and the effect of calcium channel blocker. Methods The function of PMNLs in different concentrations of glucose was examined by the release of peroxide. Results Phagocytosis function of PMNLs in diabetes was impaired and related to the concentration of glucose. Conclusion Nifedipine may improve impaired phagocytosis in diabetes patients by activa ting the L-calcium channel.

关 键 词：糖尿病 多形核白细胞 吞噬功能 钙通道阻滞剂 

分 类 号：R587.1[医药卫生—内分泌] R363[医药卫生—内科学]