合成粘合剂对胆肠吻合口愈合的影响  

Influence of OB Glue on Biliointestinal Anastomotic Wound Healing

作　　者：周林斌[1] 张莉[1] 郭善禹[1] 姚德成[1] 孙建民[1] 

机构地区：[1]上海第二医科大学第九人民医院外科,上海200011

出　　处：《上海第二医科大学学报》2001年第5期440-443,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的为了克服丝线缝合加重瘢痕形成使胆肠吻合口的狭窄。　方法用合成粘合剂 (OB胶 )替代缝线 ,结合内支撑导管建立了各种胆肠吻合口瘢痕动物实验模型 ,并定期对吻合口瘢痕组织进行病理形态学观察和生化胶原含量测定 (BCC) ,从瘢痕形成的角度观察胆肠吻合口愈合过程。　结果OB胶可促进吻合口愈合 ,减少瘢痕形成 ,加速瘢痕成熟软化 ;内支撑保留 6个月瘢痕成熟。　结论OB胶克服了丝线缝合加重瘢痕形成的不足 ,是预防胆道损伤修复重建术后吻合口狭窄的一种有效措施。Objective To overcome the drawbacks of conventional suture technique in the reconstruction of the bile duct which may often cause anastomotic stenosis and eventual obstructive jaundice and biliary cirrhosis. Methods OB glue was used instead of returing the biliointestinal anastomotic stroma where an indwelling stent was inserted in the experimental model. The experiment works consisted of pathological study and biochemical collagen content (BCC) evaluation of the anastomotic specimens were carried out in whole process of anastomotic wound healing. Results The OB glue does promote wound healing, limit scar formation and accelerate scar softening and maturation. OB glue plus indwelling a stent for 6 months can hasten scar maturation. Conclusion The application of OB glue conglutinate is an effective method in the prevention of bile duct stricture in biliointestinal anastomosis.

关 键 词：合成粘合剂 胆肠吻合 瘢痕 胆道损伤 重建术 

分 类 号：R657.4[医药卫生—外科学]