水半夏提取物的药理研究  

Pharmacological Study on the Extracts from Typhonium flagelliforme Blume

作　　者：钟正贤[1] 周桂芬[1] 陈学芬[1] 黄平[1] 

机构地区：[1]广西中医药研究所,南宁530022

出　　处：《中药材》2001年第10期735-738,共4页Journal of Chinese Medicinal Materials

基　　金：广西自然科学基金(桂科自 9811009)

摘　　要：目的:探讨水半夏的药理作用。方法:采用浓氨喷雾和酚红测定法观察止咳、祛痰作用;按整体喷雾致喘法观察平喘作用;用醋酸扭体法和二甲苯耳肿法观察镇痛抗炎作用;用自主活动实验观察镇静作用;用小鼠急性毒性试验观察其毒性情况。结果:水半夏水提物、醇提物和酯提物均能明显减少小鼠咳嗽次数和增加气管酚红排出量;延长哮喘潜伏期;减少扭体次数和抑制耳廓肿胀;减少自主活动次数。结论:水半夏水提物、醇提物和酯提物均有止咳、祛痰、平喘、镇痛、抗炎和镇静作用。其急性毒性最大耐受量,水提物为720g生药/kg,醇提物为900g生药/kg,酯提物为3240g生药/kg。Objective: To study the pharmacological action of Typhonium flagelliforme Blune(TFB) . Methods: Relieving a cough and e-liminating expectoration were observed by strong aqua spray and pheol red determining methods. The antasthmatic action was observed by whole spraying method. The analgesia and anti-inflammation were studied by the twisting test induced by acetic acid and ear swelling induced by xy-lene. The sedation was determined by autonomic action test. The toxicity of TFB was studied through the acute toxicity test in mice. Results: All the water, alcohol and ester extracts of TFB could significantly decrease cough times, increase phenol red outage in trachea, prolong asthma incubation period, decrease twisting times, inhibit ear swelling and decrease autonomic action times. Conclusion: All water, alcohol and ester extracts of TFB have effects of relieving a cough, eliminating expectoration, antasthmatic, analgesia, anti-inflammation and sedation. The maximum tolerances of TFB for acute toxicity were 720 g/kg(water extract), 900g/kg (alcohol extract) 3240g/kg (ester extract) respectively.

关 键 词：水半夏提取物 止咳祛痰 平喘镇静 镇痛抗炎 急性毒性 药理 

分 类 号：R285[医药卫生—中药学]