降纤酶治疗不稳定心绞痛的临床观察  

Acute phrase efficacy of Defibrase for injection in the treatment of unstable angina pectoris

作　　者：张瑞萍[1] 李秋荣[1] 朱萍[1] 

机构地区：[1]贵州省毕节地区医院心内科,551700

出　　处：《贵州医药》2001年第7期599-600,共2页Guizhou Medical Journal

摘　　要：目的探讨降纤酶治疗不稳定型心绞痛（ＵＡＰ）的疗效。方法将３８例新近发生的静息性心绞痛持续时间＞１５ｍｉｎ的患者随机分组：Ａ组（１８例）给予口服阿司匹林（１００ｍｇ／ｄ）和抗心绞痛药物； Ｂ组（２０例）给予阿司匹林和抗心绞痛药物加静滴降纤酶（ １０ｕ加入生理盐水 １００ｍｌ中滴注，连续 ７天）。结果Ａ组和Ｂ组在住院７天内再发心绞痛、非致死性心肌梗死，心性死亡分别为３３％与１０％，１７％与０，１１％与０，总的心脏事件发生率为７８％与１５％（Ｐ＜０．０１）。Ｂ组仅３例发生皮下淤斑。结论ＵＡＰ患者急性期用降纤酶治疗有效，安全又方便。Objective To determine the therapeutic effect of defibrase for injection in unstable angina pectoris (UAP). Methods 38 patients with UAP defined as recent onset and prolonged (≥15min) and spontaneous rest pain entered the study. Patients were randomized to receive antianginal agents plus aspirin (100 mg/d) [group A = 18] and antianginal agents plus aspirin defibrase for injection (10 μ add 100ml normal saline once daily venous transfusion [group B = 201]. Results The results showed that that recurrent angina,nonfatal myocardial infarction, cardiac death occurred in 33% vs 10%, 17%vs 0, 11% vs 0 in group A and B, respectively. Total cardiac events occurred in 78% vs 15% in group A and B (P < 0.01 ). Minor bleeding was detected in 3 patients in group B. Conclusion Treatment with defibrase for injection during acute phrase of UAP was efficient, safe and convenient.

关 键 词：不稳定心绞痛 降纤酶 治疗 疗效 

分 类 号：R541.405[医药卫生—心血管疾病]