胰岛素抵抗高血压大鼠左室肥厚的研究  

A study of the left ventricular hypertrophy in insulin resistant hypertensive rats

作　　者：李忠艳[1] 李长育[1] 花丽艳[1] 李适[1] 刘永娥[1] 

机构地区：[1]大连医科大学附属第二医院心内科,辽宁大连116023

出　　处：《心血管康复医学杂志》2001年第3期200-204,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :探讨胰岛素抵抗时高血压及左室肥厚 (L VH)形成的可能机制。方法 :以 13只高蔗糖喂养形成的胰岛素抵抗高血压大鼠 (IRHR)和 10只正常对照 SD大鼠为研究对象 ,观察其 L VH指标 (左室相对重量及心肌组织羟脯氨酸含量 ) ,并进行相关性分析及形态学观察。结果 :IRHR组血压、血清胰岛素、左室相对重量、心肌组织羟脯氨酸含量均明显高于对照组 ,其胰岛素敏感指数明显降低。形态学观察发现其左室心肌细胞明显肥大 ,间质胶原纤维明显增多。相关分析发现血压、左室相对重量、心肌组织羟脯氨酸含量均与血清胰岛素呈正相关 ,与胰岛素敏感指数呈负相关。结论 :高蔗糖饲料喂养 SD大鼠可以形成胰岛素抵抗和高血压 ,其高血压及 L VH的形成与胰岛素抵抗 ,代偿性高胰岛素血症有关。胰岛素抵抗可能是高血压性 LObjective:To study the possible mechanisms by which hypertension and left ventricular hypertrophy(LVH) are formed in insulin resistance.Methods:The insulin resistant hypertensive rats(IRHR) model(n=13) was reproduced by feeding sprague\|dawley(SD) rats for 8 weeks on a high\|sucrose chow.Normal SD rats (n=10) were studied as a control group.Left ventricular relative mass(LVSW/BW),L\|Hydroxyproline(H\|pro) content in myocardial tissue and morphological changes were investigated.Results:(1)Blood pressure(BP) and serum insulin,LVSW/BW and H\|pro content in myocardial tissue in IRHR were higher than those in control group,insulin sensitive index(ISI) was lower in IRHR;(2)BP,LVSW/BW,H\|pro were significantly correlated with serum insulin positively and with ISI inversely;(3)Myocardial cellular hypertrophy and increased interstitial collagenous fibers were found in IRHR by optical microscope and electron microscope.Conclusion:(1)High\|sucrose feeding can induce insulin resistance(IR) and hypertension in the SD rats.Hypertension may be related to IR and compensatory hyperinsulinemia;(2)The formation of LVH in IRHR including myocardial cellular hypertrophy and interstitial fibrosis,may be not only due to high BP,but also to IR and compensatory hyperinsulinemia.

关 键 词：高血压 胰岛素抵抗 高胰岛素血症 左室肥厚 LVH EA IR HIS 

分 类 号：R544.1[医药卫生—心血管疾病] R977.15[医药卫生—内科学]