线粒体DNA用作分子标记的可靠性和研究前景  

Reliability of mtDNA as Molecular Marker and Its Perspective

作　　者：牛屹东[1] 李明[1] 魏辅文[1] 冯祚建[1] 

机构地区：[1]中国科学院动物研究所,北京100080

出　　处：《遗传》2001年第6期593-598,共6页Hereditas（Beijing)

基　　金：中国科学院"青年科学家创新小组"专项基金;国家自然科学基金 (No.39730 0 80和No .39970 10 3);大科学工程和特殊学科人才培养项目资助

摘　　要：mtDNA作为分子标记的广泛应用 ,使得系统进化、生物地理、群体遗传、人类学及法医鉴定等领域的研究得到前所未有的发展。但随着对线粒体基因组遗传特性的了解不断加深 ,以mtDNA作为分子标记的潜在问题便逐渐暴露出来。本文从 7个方面对mtDNA应用的可靠性问题进行了讨论 ,并对今后线粒体基因的应用前景做了初步分析。With some special features,mtDNA is used widely as molecular marker in the fields of systematic evolution,biogeography,population genetics,anthropology,and forensic medicine.However,more and more evidences that challenge the traditional concept on mtDNA features are found increasingly.In this paper,seven facts that could affect the reliability of mtDNA used as molecular marker are reviewed,then the perspective on application of mtDNA is discussed.

关 键 词：线粒体DNA MTDNA 分子标记 可靠性 

分 类 号：Q343.35[生物学—遗传学]