兔颈总动脉动脉瘤中药白芨胶栓塞研究  

Research about Baiji glue embolization for common carotid artery aneurysms in rabbits

作　　者：丁永红[1] 戴大英[2] 程瑞新[1] 耿坚[1] 朱琼[1] 黄学箐[1] 丁乃时[1] 张善生[1] 张忠[1] 罗其中[3] 

机构地区：[1]上海中医药大学附属曙光医院放射科,上海200021 [2]上海同济医院病理科,上海200321 [3]上海第二医科大学附属仁济医院神经外科,上海200001

出　　处：《中国微侵袭神经外科杂志》2001年第3期139-141,共3页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的 探讨动脉瘤中药白芨胶液体栓塞的可行性。 方法 应用显微外科技术建立10只兔颈总动脉侧壁动脉瘤。将超微导管插至动脉瘤腔并进行中药白芨胶液体栓塞，通过数字减影血管造影及组织病理标本观察栓塞前后瘤腔及载瘤动脉发生的血流动力学改变。 结果 栓塞后即刻血管造影显示7只瘤腔全部闭塞，3只瘤腔大部被白芨栓塞。栓塞后半年组织病理标本示10只动脉瘤瘤腔均完全闭塞，8只动脉瘤远端载瘤动脉通畅，2只动脉瘤远端载瘤动脉闭塞。未见血管壁明显炎症及远端组织缺血表现。 结论 应用中药白芨胶栓塞动脉瘤具有可行性。Objective To explore the possibility of Baiji embolization for aneurysms． Method l0 common carotid artery side－wall aneurysms were established by microsurgical technique in rabbits． Ultra－microcatheter was inserted into aneurysm lumen and Baiji liquid was injected to obliterate the aneurysm． Digital subtractive angiography and histopathologic examination were done to observe hemodynamic changes of aneurysm lumen and parent artery． Result 7 aneurysms were completely obliterated immediately after embolization,3 aneurysms were partialy obliterated． After 6 months of embolization,all the l0 aneurysms showed complete obliteration by histopathologic examination,8 parent arteries remained unobstructed,2 distal parent arteries were obliterated,no obvious vessel－wall inflammation and no distal tissue ischemia was found after Baiji glue embolization． Conclusion Baiji glue embolization for aneurysms is possible．

关 键 词：动物模型 白芨胶 栓塞 颅内动脉瘤 

分 类 号：R651.12[医药卫生—外科学]