中西医结合治疗实验性狼疮样肾炎疗效观察  

Treatment of Lupus-like Nephritis With Prednisone Plus Traditional Chinese Medinicine

作　　者：董光富[1] 叶任高[1] 王俭勤[1] 李幼姬[1] 杨念生[1] 

机构地区：[1]中山医科大学附属第一医院肾内科,广州510080

出　　处：《中国中西医结合肾病杂志》2001年第7期378-380,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：中山医科大学 2 11工程重点科研基金资助项目 (No 9815 1);广东省中医药管理局基金资助项目 (No98375 )

摘　　要：目的 :了解用强的松、自拟中药方剂和强的松加自拟中药方剂治疗狼疮样肾炎 (LN)的疗效。方法 :先建立狼疮样肾炎鼠模型 -慢性移植物抗宿主病 (cGVHD)模型 ,动态观察对照模型组 2、4、6、8、10、12、14周和 3种不同治疗方案组治疗后 2、4、6、8周时尿白蛋白、血抗dsDNA和血肌酐 (Scr)水平 ,尿白蛋白和血抗dsDNA水平测定分别采用放免法和酶联免疫吸附法 (ELISA)。结果 :3种治疗方案均能明显降低cGVHD鼠尿白蛋白和血抗dsDNA水平及治疗终点时的Scr ;对照模型组、单用激素组、单用中药组和激素加中药组于治疗后 2、4、6、8周时的尿白蛋白和血抗dsDNA水平 ,各组间比较均有明显差异 ,P <0 0 5。结论 :三种方案对治疗LN均有效 ,强的松联用自拟中药方剂方案治疗狼疮样肾炎优于单用激素或单用中药方剂方案。Objective:To study effect of prednisone,traditional Chinese medicine(“Lupus Prescription”)and traditional Chinese medicine plus prednisone on lupus-like nephritis.Methods:Chronic graft versus host disease(cGVHD)mouse model was established.Urine albumin,serum anti-dsDNA and creatine(Scr)level were monitored in cGVHD mice witbout treatment at 2,4,6,8,10,12,14 weeks after induction of disease and in cGVHD mice with three different treatments at2,4,6,8 weeks after induction.Results:Comparing with cGVHD mouse without treatment,urine albumin,serum anti-dsDNA and Scr level were significantly reduced in all three treatment groups.There was a significant difference(P<0.05)in urine albumin or serum anti-dsDNA among traditional Chinese medicine group,prednisone group and prednisone plus traditional Chinese medicine group.Conclusion:All three treatment protocols were effective for Lupus-like nephritis.Prednisone plus traditional Chinese medicine is superior to prednisone or traditional Chinese medicine alone.

关 键 词：实验性疮样肾炎 CGVHD 方剂 强的松 中西医结合疗法 疗效研究 

分 类 号：R593.242[医药卫生—内科学]