基质金属蛋白酶-1在表皮修复中的生物学作用  

THE BIOLOGICAL EFFECT OF MATRIX METALLOPROTEINASE-1 IN EPIDERMAL REPAIR

作　　者：胡大海[1] 陈壁[1] 

机构地区：[1]第四军医大学西京医院烧伤外科,西安710032

出　　处：《中国修复重建外科杂志》2001年第4期248-251,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　阐明有关基质金属蛋白酶 - 1(MMP- 1)在皮肤损伤后 ,表皮修复过程中的作用。方法　回顾近年来有关 MMP- 1在皮肤损伤修复中的作用及研究进展 ,总结其在上皮化局部微小环境内的表达及细胞分子生物学效应。结果　皮肤损伤信号直接引发表皮细胞于特定的部位及时间表达 MMP- 1;MMP- 1通过特异性分解创面基质胶原蛋白 ,促进表皮细胞的增殖及迁移 ,由此影响表皮损伤创面的愈合结果。结论　皮肤损伤后表皮细胞表达 MMP-Objective To review the role of matrix metalloproteinase 1 (MMP 1) in the course of healing in wounded skin. Methods The recent literatures on MMP 1 in skin wound repair were reviewed, which gave the insight into the local effect of MMP 1 during re epithelialization. Results Following injury, basal keratinocytes, moving from the wound edge and interact with dermal matrix proteins in the wound bed, were induced to express MMP 1 in a specific space time pattern. MMP 1 cleaved the collagen, thereby altering its structure and affinity by which the keratinocytes binded it. MMP 1 served a beneficial role in wound healing by facilitating the proliferation and movement of keratinocytes over the collagen rich wound bed during re epithelialization. Conclusion MMP 1 expression of migrating keratinocytes directly influences the re epithelialization during the course of healing of the wounded skin.

关 键 词：基质金属蛋白酶-1 细胞外基质 表皮 修复 生物学作用 皮肤损伤 

分 类 号：R602[医药卫生—外科学]