毒素清对肺炎双球菌肺炎老龄大鼠自由基和前列腺素代谢的影响  

Influence of "Toxin Remover" on Free Radicals and Prostaglandin Metabolism of Senile Rats with Pneumococcal Pneumonia

作　　者：李建生[1] 郭盛典[1] 李贻奎[1] 张杰[1] 

机构地区：[1]河南中医学院老年医学研究室,河南郑州450003

出　　处：《上海中医药大学学报》2001年第4期55-57,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：河南高校创新人才基金资助 ( 2 0 0 0 10 )

摘　　要：研究毒素清对老年肺炎的作用机制。将 32只SD老年大鼠肺炎双球菌肺炎模型 ,分为B、C、D、E四组 ,另取 8只相同未造模的大鼠作为正常对照组。C、D、E组分别予毒素清高、低剂量、头孢氨卡灌胃 ,A、B组以等量生理盐水灌胃。观察肺脏组织病理改变 ,外周血前列腺素代谢产物 ,肺泡灌洗液中性粒细胞计数、SOD活性、NO和MDA含量。结果 :肺炎老龄大鼠的肺组织损伤明显。与A组比较 ,B组肺泡灌洗液中性粒细胞和血浆TXB2 含量增高 ,血浆 Keto PGF1a含量降低 ,血清和肺泡灌洗液SOD活性下降和NO、MDA含量增高。高剂量毒素清治疗后 ,外周血SOD活性和6 -Keto PGF1a含量升高 ,血清和肺泡灌洗液MDA含量降低 ,肺泡灌洗液NO含量和血浆TXB2 含量下降。提示毒素清对老龄大鼠肺炎的作用明显 ,其机制与其降低中性粒细胞数量和拮抗自由基损伤及调节前列腺素代谢平衡有关。In order to study the functional mechanism of 'Toxin Remover'on senile pneumonia,after modeled with pneumococcal pneumonia,32 SD senile rats were divided into the groups of B,C,D and E,together with 8 non-modeled rats as the control group.Groups C,D and E were fed with high dose and lower dose of'Toxin Remover'and cephalosporin and Group A and B were fed with the same amount of physiological saline to observe pathological change of the pulmonary tissues,prostaglandin metabolite in peripheral blood,neutrophil count in lavage solution of pulmonary alveoli,SOD activity,NO and MDA contents.The results showed that the damage in the pulmonary tissues of the senile rats with pneumonia was obvious.In comparison of the Group A,in Group B,the neutrophil in lavage solution of the pulmonary alveoli and plasma TXB 2 content were elevated,and plasma-Keto-PGF 1α content was decreased,and serum and SOD activity in lavage solution of pulmonary alveoli was decrease and NO and MDA contents were elevated.After treated with high dose of 'Toxin Remover',SOD activity in peripheral blood and 6-Keto-PGF 1α contents were elevated,and MDA content in serum and lavage solution of pulmonary alveoli was decreased,and NO content in lavage solution of the pulmonary alveoli and plasma TXB 2 content were decreased.The findings indicate that the function of'Toxin Remover' is obvious to senile rats with pneumonia and its mechanism is related to its effects to decrease neutrophil count and resist damage in free radicals and regulate prostaglandin metabolism.

关 键 词：肺炎双球菌肺炎 前列腺素 自由基 毒素清 细菌性肺炎 

分 类 号：R285.5[医药卫生—中药学]