慢性支气管炎及其急性发作患者止凝血变化的研究  

作　　者：郑彤[1] 刘洪斌[2] 卓益奋 葛雪莲[4] 戴友良[1] 

机构地区：[1]浙江宁波市医疗中心李惠利医院检验科,315040 [2]宁波大学医学院生化教研室,315211 [3]浙江省奉化市人民医院,315504 [4]浙江宁波市妇女儿童医院,315010

出　　处：《浙江临床医学》2001年第10期705-706,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 观察慢性支气管炎 (简称慢支 )和慢性支气管炎急性发作 (简称慢支急发 )患者止凝血指标水平的变化 ,探索其变化的机理和临床意义。方法 采用双抗体夹心ELISA法、发色底物法和免疫浊度法对46例慢支患者 ,32例慢支急发患者以及44例健康对照者的止凝血指标进行检测。这些指标包括 :vWF :Ag、FⅡa:A、TFPI、GMP -140、DH -TXB2、D -D。结果 慢支组、慢支急发组与对照组比较 ,各指标均显著升高 (p<0.05、p<0.01) ;慢支急发组与慢支组比较 ,各指标亦显著升高 (p<0.05、p<0.01)。结论 慢支尤其慢支急发患者由于低氧血症、组织受炎症刺激等因素 ,引起内皮细胞损伤 ,血液处于高凝、高粘、微血栓形成和纤溶亢进状态 ,这些状态又可进一步加重病情。Objective To observe the blood coagulation changes in chronic bronchitis cases with acute attacks so as to explore the mechanisms and clinical significance. Methods By using ELISA, substrate and immune turbidity, detections of the blood coagulation factors (vWF, Ag, FIIa:A, TFPI,GMP-140, DH-TXB2 and D-D) were made on the 46 chronic bronchitis cases, 32 chronic bronchitis cases with acute attacks and 44 healthy control cases. Results Compared with the control, the raised detection levels were found in the 46 chronic bronchitis cases and 32 chronic bronchitis cases with acute attacks (P<0.01). They were also higher in the 32 chronic bronchitis cases with acute attacks than those in the 46 chronic bronchitis cases (P<0.05). Conclusion Chronic bronchitis and chronic bronchitis with acute attacks cases had hypoxemia, inflammation stimulation, which led to the endothelial cell damage, hypercoagulability, hyperviscosity, formation of microthrombus, hyperfibrinolysis. All these factors could deteriorate the disease.

关 键 词：慢性支气管炎 慢性支气管炎急性发作 低氧血症 止凝血 临床研究 

分 类 号：R562.21[医药卫生—呼吸系统]