犬埃立克体动物感染实验  

Studies on Beagle Dogs and C_3H Mice Experimentally Infected with Ehrlichia canis

作　　者：马玉海[1] 潘华[1] 佟世德[1] 陈香蕊[2] 孙洋[1] 张雪颍[2] 莫卓寿 

机构地区：[1]广州军区军事医学研究所,广州510507 [2]军事医学科学院流行病微生物研究所,北京100071

出　　处：《实验动物科学与管理》2001年第3期1-4,共4页Laboratory Animal Science & Administration

基　　金：全军"九五"医学科研规划课题 (98M0 35 )

摘　　要：为探讨比格犬和C3H小鼠对犬埃立克体的敏感性 ,建立犬埃立克体病实验模型 ,用我国埃立克体病病犬血白细胞分别接种比格犬和C3H小鼠。接毒后比格犬和C3H小鼠均为PCR阳性 ,比格犬与最易感的德国牧羊犬自然感染埃立克体病的临床表现和病理学变化基本一致。Objective to study the susceptibility of Beagle dogs and C 3H mice to infection with Ehrlichia canis,and establish laboratory model of canine ehrlichiosis.The leucocyte of German shepherd who suffer from canine ehrlichiosis in China were inoculated to Beagle dogs and C 3H mice.They appeared to be infection by the test of PCR.The artificial infected Beagle dogs were very similar to natural infected German shepherds in clinical manifestation and pathological changes.It is concluded that Beagle dogs and C 3H mice were susceptible to E.canis,and a new laboratory model of canine ehrlichiosis was successfully developed in Beagle dogs.

关 键 词：犬埃立克体 犬埃立克体病 比格犬 C3H小鼠 感染实验 

分 类 号：S852.64[农业科学—基础兽医学] S858.292[农业科学—兽医学]